{"id":"W4402553041","doi":"10.1093/neuonc/noae157","title":"<i>MGMT</i> promoter methylation and survival following chemotherapy for WHO grade 4 IDH-mutant astrocytoma","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre","funders":"","keywords":"Methylation; Astrocytoma; Mutant; Cancer research; Biology; Chemotherapy; Oncology; Medicine; Genetics; Glioblastoma; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002488429,0.0001232281,0.0002420262,0.0004812082,0.0002537537,0.0003190934,0.0002619167,0.000243034,0.001396388],"category_scores_gemma":[0.001350054,0.00008987702,0.0003754538,0.0007097729,0.0001347389,0.0003445862,0.0002664024,0.0004182443,0.0002558017],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005634481,"about_ca_system_score_gemma":0.0004658276,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008594907,"about_ca_topic_score_gemma":0.01499199,"domain_scores_codex":[0.9998494,0.00002169382,0.00001852918,0.00003342126,0.00003337059,0.00004359657],"domain_scores_gemma":[0.9990682,0.0001001474,0.0005512247,0.00004377306,0.00007676574,0.0001599473],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0006283821,0.00004041997,0.991616,0.0000177099,0.00007971277,0.00009896961,0.00003100804,0.0001354034,0.0001825193,0.00002080908,0.0009456931,0.006203471],"study_design_scores_gemma":[0.00001424742,0.0001682374,0.9984511,0.00001585227,0.00008352886,0.0001939515,0.00004495026,0.000308554,0.00009665189,0.00008564435,0.0005329921,0.000004213987],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963422,0.0009849861,0.00006219941,0.0002396674,0.00002245314,0.00001052473,0.001467558,0.00001039515,0.0008599103],"genre_scores_gemma":[0.9973605,0.0003800686,0.0000638721,0.00009915883,0.00003685165,0.0000125044,0.001786918,0.000004912181,0.000255203],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008594907,"threshold_uncertainty_score":0.01708972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02646314714540738,"score_gpt":0.3285658917906031,"score_spread":0.3021027446451958,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}