{"id":"W4402554892","doi":"10.1136/bmjopen-2024-085652","title":"Cohort profile: DNA methylation in the Northern Ireland Cohort for the Longitudinal Study of Ageing (NICOLA) – recruitment and participant characteristics","year":2024,"lang":"en","type":"article","venue":"BMJ Open","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Economic and Social Research Council; Office of the First Minister and Deputy First Minister; Queen's University; UK Research and Innovation; Wellcome Trust; Queen's University Belfast; Canadian Institute for Theoretical Astrophysics; Health and Social Care Research and Development Division; Medical Research Council; Centre for Ageing Research and Development in Ireland; Atlantic Philanthropies","keywords":"Medicine; Cohort; Ageing; Cohort study; Longitudinal study; Epidemiology; DNA methylation; Gerontology; Family medicine; Demography; Internal medicine; Genetics; Pathology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002082191,0.0003794658,0.0004457316,0.001163411,0.0007932879,0.0006894239,0.001119897,0.0005093652,0.003946449],"category_scores_gemma":[0.003866828,0.0003471882,0.0006393958,0.0014316,0.0002212444,0.000497676,0.001312146,0.0006205317,0.001553654],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00135608,"about_ca_system_score_gemma":0.001609285,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.06641022,"about_ca_topic_score_gemma":0.09302539,"domain_scores_codex":[0.9988365,0.0003127935,0.0001377118,0.0003091347,0.0002050318,0.0001988519],"domain_scores_gemma":[0.9984018,0.00008321244,0.0003608993,0.0003071869,0.0005953913,0.0002515769],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001568521,0.0001470459,0.9596928,0.000237224,0.000278914,0.0002330302,0.0006253809,0.0001695561,0.001168987,0.0002137929,0.02520849,0.01045624],"study_design_scores_gemma":[0.0001189162,0.000217724,0.9864391,0.0001312705,0.000100149,0.0003708169,0.000448663,0.0001819756,0.0002449169,0.00005356362,0.01166483,0.00002812198],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8504854,0.001559486,0.002806553,0.0007133015,0.0001332604,0.003554313,0.130696,0.0001590353,0.009892705],"genre_scores_gemma":[0.8879191,0.0006816993,0.006373731,0.001037308,0.0001091839,0.01027068,0.0824982,0.0001184375,0.01099162],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06641022,"threshold_uncertainty_score":0.1320474,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1866408834796809,"score_gpt":0.4312615969994649,"score_spread":0.244620713519784,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}