{"id":"W4402555087","doi":"10.1002/art.42989","title":"<scp>TLR7</scp>/8 Activation in Immune Cells and Muscle by <scp>RNA</scp>‐Containing Immune Complexes: Role in Inflammation and the Pathogenesis of Myositis","year":2024,"lang":"en","type":"article","venue":"Arthritis & Rheumatology","topic":"Inflammatory Myopathies and Dermatomyositis","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"EMD Serono; NYU Grossman School of Medicine; York University; Massachusetts General Hospital","keywords":"TLR7; Immune system; Inflammation; Immunology; Myositis; Peripheral blood mononuclear cell; Autoantibody; Dermatomyositis; Polymyositis; Toll-like receptor; Biology; Molecular biology; Medicine; Antibody; Innate immune system; Internal medicine; Biochemistry; In vitro","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001553484,0.0002401517,0.0002010277,0.000223609,0.0001603024,0.000188714,0.00009148668,0.0002358114,0.002018076],"category_scores_gemma":[0.0001659867,0.00006634848,0.0001962373,0.0001426622,0.0001773676,0.00009914526,0.0001633826,0.000170314,0.000430346],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001613009,"about_ca_system_score_gemma":0.0001080578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002124072,"about_ca_topic_score_gemma":0.0002377824,"domain_scores_codex":[0.9998523,0.00002736699,0.00001796185,0.00003954603,0.0000344309,0.00002833079],"domain_scores_gemma":[0.9999063,0.00001676921,0.00003673737,0.000007582313,0.0000148211,0.00001786405],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006131386,0.00004068051,0.02104304,0.00009798473,0.00002823443,0.0005282856,0.00004032068,0.0001211639,0.9721611,0.00005254222,0.0001759278,0.005097494],"study_design_scores_gemma":[0.0001454514,0.002732599,0.3985634,0.00005746914,0.0001284374,0.01001067,0.0003194626,0.001961862,0.5807028,0.0001894783,0.005172673,0.00001572296],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979731,0.0006565121,0.0004691249,0.00004236772,0.000005564839,0.00001618521,0.0001498809,0.00001276594,0.0006744307],"genre_scores_gemma":[0.9981954,0.0002158766,0.0006185741,0.00004960433,0.00001538969,0.00003327782,0.0003321259,0.00000435385,0.0005356502],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002018076,"threshold_uncertainty_score":0.00675112,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004340348515548425,"score_gpt":0.2077849919023328,"score_spread":0.2034446433867844,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}