{"id":"W4402555087","doi":"10.1002/art.42989","title":"<scp>TLR7</scp>/8 Activation in Immune Cells and Muscle by <scp>RNA</scp>‐Containing Immune Complexes: Role in Inflammation and the Pathogenesis of Myositis","year":2024,"lang":"en","type":"article","venue":"Arthritis & Rheumatology","topic":"Inflammatory Myopathies and Dermatomyositis","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"EMD Serono; NYU Grossman School of Medicine; York University; Massachusetts General Hospital","keywords":"TLR7; Immune system; Inflammation; Immunology; Myositis; Peripheral blood mononuclear cell; Autoantibody; Dermatomyositis; Polymyositis; Toll-like receptor; Biology; Molecular biology; Medicine; Antibody; Innate immune system; Internal medicine; Biochemistry; In vitro","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008403307,0.0002942965,0.0009454943,0.0003983621,0.0001432614,0.0000794638,0.0001134381,0.0002673128,0.00001227915],"category_scores_gemma":[0.0004180997,0.0002685001,0.0001010701,0.0004117668,0.000442268,0.0003700233,0.0001361948,0.0003890649,0.00001333982],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006224157,"about_ca_system_score_gemma":0.0000868842,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001296102,"about_ca_topic_score_gemma":0.0003313185,"domain_scores_codex":[0.9973699,0.000352256,0.001131346,0.0004336162,0.0002322594,0.0004806136],"domain_scores_gemma":[0.9974912,0.001758523,0.0002635705,0.0003117424,0.00008742486,0.00008754569],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001502015,0.0001102321,0.03323839,0.001037729,0.0001509904,0.0003809816,0.02583703,0.00002875841,0.8297245,0.01690701,0.0007606379,0.09167357],"study_design_scores_gemma":[0.0274568,0.001101727,0.5486487,0.01037324,0.0001757508,0.004912464,0.03649283,0.0107611,0.3314371,0.006930791,0.02125394,0.0004555574],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9587505,0.03904116,0.0001154805,0.0004308315,0.0001732967,0.0006720006,0.00002949336,0.0000761196,0.0007110649],"genre_scores_gemma":[0.9865966,0.01281766,0.0001750218,0.0000876613,0.00002397898,0.000124107,0.00008610107,0.00004678525,0.00004210831],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5154103,"threshold_uncertainty_score":0.9999767,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004340348515548425,"score_gpt":0.2077849919023328,"score_spread":0.2034446433867844,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}