{"id":"W4402560107","doi":"10.1016/j.annonc.2024.08.687","title":"620P Efficacy, safety and PKPD of 23ME-00610, a first-in-class anti-CD200R1 antibody, in patients with tumor mutational burden-high (TMB-H) and/or microsatellite instability-high (MSI-H) cancers: Results from an expansion cohort","year":2024,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Medicine; Microsatellite instability; Antibody; Cancer research; Oncology; Microsatellite; Genetics; Immunology; Gene; Allele","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007619304,0.0003390213,0.0005794372,0.000193896,0.0001746091,0.0006251917,0.0002579206,0.0003763834,0.001461621],"category_scores_gemma":[0.0007123835,0.0001628642,0.000538596,0.0002081735,0.0003294035,0.0006027774,0.0002361948,0.0008247787,0.0005903803],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004184637,"about_ca_system_score_gemma":0.0003207958,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006058418,"about_ca_topic_score_gemma":0.0006709881,"domain_scores_codex":[0.9996672,0.00008763734,0.00001721641,0.0001010837,0.0000665386,0.00006045918],"domain_scores_gemma":[0.9997007,0.00006691609,0.00005905533,0.00005479568,0.00003085845,0.00008763876],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.1975909,0.008595018,0.3653652,0.0002124831,0.002294441,0.0009874954,0.0005367726,0.003772963,0.08941982,0.0003365099,0.004697152,0.3261913],"study_design_scores_gemma":[0.01962852,0.1401012,0.8053309,0.00004809386,0.002213063,0.002114527,0.0002638768,0.004029427,0.01676443,0.0005485113,0.008880902,0.00007653159],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982609,0.0004136303,0.00008390732,0.00005275214,0.000009801282,0.00002261967,0.0003058304,0.00001206504,0.0008384465],"genre_scores_gemma":[0.9977199,0.0002245452,0.00008367778,0.0001156916,0.00002389169,0.00002444038,0.0008178438,0.000008748744,0.0009810766],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001461621,"threshold_uncertainty_score":0.004889607,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01972901902030418,"score_gpt":0.3282027910193738,"score_spread":0.3084737719990696,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}