{"id":"W4402560117","doi":"10.1016/j.annonc.2024.08.671","title":"604O Phase I dose escalation and initial dose expansion results of AMG 193: A MTA-cooperative PRMT5 inhibitor, in patients (pts) with MTAP-deleted solid tumors","year":2024,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Medicine; Maximum tolerated dose; Pharmacology; Nuclear medicine; Adverse effect","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002660239,0.0001639298,0.0003065157,0.0001713345,0.00002854936,0.000009751311,0.00006383177,0.0002676872,0.000005728974],"category_scores_gemma":[0.0001176753,0.00014553,0.00004969948,0.0002576794,0.0001753803,0.00002109439,0.0000633587,0.0001274048,0.000001560842],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003394481,"about_ca_system_score_gemma":0.0003445442,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008962105,"about_ca_topic_score_gemma":0.0002998475,"domain_scores_codex":[0.9985605,0.0001563562,0.0005417372,0.0003909539,0.000154497,0.0001959317],"domain_scores_gemma":[0.9991843,0.0000400353,0.0002159597,0.000183074,0.000314796,0.00006187426],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01892112,0.001756067,0.001036063,0.0001725153,0.000249214,0.0000365278,0.00221678,0.005085947,0.7721171,0.00005465429,0.003740753,0.1946133],"study_design_scores_gemma":[0.01880701,0.02989953,0.02613685,0.0005048912,0.00007323697,0.00002244323,0.0002081066,0.004085391,0.9128912,0.0001045173,0.006831883,0.0004349484],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998056,0.000495008,0.00009421295,0.0003874396,0.0001388065,0.0004267352,0.0001037103,0.00001006848,0.0002879963],"genre_scores_gemma":[0.9987734,0.0001986715,0.000136223,0.00008014882,0.0001213552,0.00002466419,0.0006001919,0.00002067563,0.00004464918],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1941783,"threshold_uncertainty_score":0.5934542,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02474736697317593,"score_gpt":0.3549713254129717,"score_spread":0.3302239584397957,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}