{"id":"W4402560917","doi":"10.1016/j.annonc.2024.08.1129","title":"1071TiP Phase I study of the investigational CD228 x 4-1BB costimulatory antibody anticalin bispecific SGN-BB228 (PF-08046049) in advanced melanoma and other solid tumors","year":2024,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; McGill University; Jewish General Hospital","funders":"","keywords":"Medicine; Bispecific antibody; Melanoma; Antibody; Cancer research; Oncology; Immunology; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005827975,0.001047019,0.001435993,0.000351753,0.0003083428,0.0007928205,0.0006333834,0.0008262265,0.003381626],"category_scores_gemma":[0.0002384419,0.0003913418,0.0007007599,0.0002898548,0.0004528105,0.0003477389,0.0002214392,0.002749245,0.001201053],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006853614,"about_ca_system_score_gemma":0.001274729,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002333419,"about_ca_topic_score_gemma":0.00483772,"domain_scores_codex":[0.9998009,0.00006873233,0.000007600234,0.00002575539,0.00002287225,0.00007420308],"domain_scores_gemma":[0.9998215,0.0000222514,0.00002010381,0.00001645674,0.00001498285,0.00010464],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.2844155,0.1168835,0.007884654,0.001334048,0.001781411,0.0007756776,0.0003578643,0.007643607,0.2812638,0.001413762,0.02354972,0.2726964],"study_design_scores_gemma":[0.2491222,0.6801735,0.01794548,0.0000870213,0.0008179476,0.0008108837,0.0001201226,0.00413571,0.03034468,0.000381857,0.01600953,0.00005114933],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862151,0.003901912,0.0008540201,0.0006351831,0.0002966613,0.001227899,0.00135,0.0001828642,0.005336392],"genre_scores_gemma":[0.9809527,0.00387891,0.001858061,0.001009223,0.0001394978,0.001437367,0.003491865,0.00005863314,0.007173747],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003381626,"threshold_uncertainty_score":0.01131272,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1250370171656766,"score_gpt":0.4862943189360423,"score_spread":0.3612573017703656,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}