{"id":"W4402561251","doi":"10.1016/j.annonc.2024.08.582","title":"513MO Amivantamab plus FOLFOX or FOLFIRI in metastatic colorectal cancer: Results from OrigAMI-1, an open-label, phase Ib/II study","year":2024,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa; Princess Margaret Cancer Centre; Ottawa Hospital; University Health Network","funders":"","keywords":"FOLFOX; FOLFIRI; Medicine; Colorectal cancer; Oncology; Internal medicine; Cancer; Oxaliplatin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001250888,0.001314302,0.001883221,0.0004678404,0.0003799307,0.001053649,0.0007497836,0.00110949,0.003152561],"category_scores_gemma":[0.0005841252,0.0004615275,0.001722018,0.0004272902,0.0007775986,0.0009153896,0.0002234112,0.002432773,0.0007051559],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001005996,"about_ca_system_score_gemma":0.00101796,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001455383,"about_ca_topic_score_gemma":0.004982508,"domain_scores_codex":[0.9997064,0.0001070362,0.00001700372,0.00005881388,0.00003515067,0.00007543875],"domain_scores_gemma":[0.999667,0.00008505344,0.00007205695,0.00003135779,0.00002205438,0.0001224124],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7007132,0.04655555,0.004002041,0.002043087,0.003820483,0.000164954,0.0002314324,0.002001878,0.06850287,0.0003252336,0.003830203,0.167809],"study_design_scores_gemma":[0.4839545,0.4775707,0.01821088,0.0001519306,0.004182506,0.0002715397,0.0001107533,0.00143614,0.009329828,0.0002501935,0.004455757,0.00007530324],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863324,0.0098844,0.0003192018,0.0004845847,0.0001840884,0.0004413968,0.0007320563,0.00007328302,0.001548518],"genre_scores_gemma":[0.9835476,0.007778754,0.001342746,0.001197687,0.0002989442,0.0004978787,0.002388937,0.00003983338,0.002907497],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003152561,"threshold_uncertainty_score":0.01054633,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2492686992421674,"score_gpt":0.5171064460490095,"score_spread":0.267837746806842,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}