{"id":"W4402561311","doi":"10.1016/j.annonc.2024.08.569","title":"500TiP Update on GBM AGILE: A global, phase II/III adaptive platform trial to evaluate multiple regimens in newly diagnosed and recurrent glioblastoma","year":2024,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; Glioblastoma; Oncology; Internal medicine; Phases of clinical research; Clinical trial; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002339798,0.0008053619,0.001773386,0.0005081437,0.0002786496,0.001546936,0.0009619751,0.001293268,0.007902034],"category_scores_gemma":[0.003287687,0.0003021317,0.001715953,0.0005080296,0.0003883224,0.001147765,0.0007051175,0.00355994,0.001607963],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009525121,"about_ca_system_score_gemma":0.001168339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001539482,"about_ca_topic_score_gemma":0.006659765,"domain_scores_codex":[0.9995197,0.0002284003,0.00003746722,0.0000508018,0.00009637904,0.00006724627],"domain_scores_gemma":[0.9986461,0.0005204849,0.0002032287,0.00007985884,0.0001702236,0.0003801874],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.05404387,0.002094443,0.002444602,0.004078782,0.00308621,0.0002025258,0.0001642671,0.002846961,0.008432537,0.002197836,0.1642583,0.7561496],"study_design_scores_gemma":[0.3479559,0.07990873,0.02396805,0.004760666,0.009529412,0.0008314988,0.0002107554,0.004896063,0.004000744,0.01012249,0.51361,0.0002057277],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.42629,0.2822146,0.01936225,0.08963095,0.0135969,0.008765073,0.05098085,0.004071244,0.1050881],"genre_scores_gemma":[0.5840515,0.172608,0.02756979,0.112671,0.00669614,0.008340538,0.04706509,0.001237597,0.0397604],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007902034,"threshold_uncertainty_score":0.0264349,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1011889110344475,"score_gpt":0.425779293027831,"score_spread":0.3245903819933836,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}