{"id":"W4402563246","doi":"10.1016/j.clinthera.2024.08.007","title":"The Totality of Evidence for SDZ-deno: A Biosimilar to Reference Denosumab","year":2024,"lang":"en","type":"review","venue":"Clinical Therapeutics","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Hexal AG","keywords":"Medicine; Biosimilar; Pharmacology; Intensive care medicine; Internal medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["research_integrity"],"consensus_categories":[],"category_scores_codex":[0.004351513,0.0004883952,0.002218144,0.00007176599,0.0001864129,0.00005686589,0.001268774,0.001551997,0.00004806431],"category_scores_gemma":[0.00201917,0.0002219815,0.001563656,0.000418628,0.0009083496,0.00002477111,0.0003863809,0.001265308,0.0002105739],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000556373,"about_ca_system_score_gemma":0.0004175545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003191931,"about_ca_topic_score_gemma":0.000007732947,"domain_scores_codex":[0.9951189,0.001366827,0.002123688,0.0007732571,0.00008604438,0.0005312391],"domain_scores_gemma":[0.9839657,0.01411,0.0004775881,0.001140051,0.0002352804,0.00007140195],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001390599,0.00009849083,0.000003060298,0.003034877,0.001528779,0.000001095624,0.00001297089,1.491955e-8,0.00001762788,0.002232121,0.008325589,0.9846063],"study_design_scores_gemma":[0.0001597621,0.0007578047,0.000005818426,0.00607487,0.004888969,0.00001036096,0.00001180569,0.000002427516,0.00005164832,0.001125949,0.9866049,0.0003057132],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000002242837,0.9933433,0.0006303116,0.001717204,0.002349765,0.001394296,0.00034605,0.00006716287,0.000149674],"genre_scores_gemma":[0.00002493483,0.9941813,0.001483615,0.001178226,0.0001760279,0.0001282262,0.00001956355,0.00005204287,0.002756048],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9843006,"threshold_uncertainty_score":0.9997442,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.8425130437616768,"score_gpt":0.6390781168110089,"score_spread":0.2034349269506679,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}