{"id":"W4402563644","doi":"10.1016/j.prenap.2024.100090","title":"Anxiolytic-like effect of daidzin possibly through GABAA receptor α2 and α3 subunits interaction pathway: In vivo and in silico studies","year":2024,"lang":"en","type":"article","venue":"Pharmacological Research - Natural Products","topic":"Phytoestrogen effects and research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Innovation Cluster (Canada)","funders":"Khulna University; University Grants Commission","keywords":"Daidzin; GABAA receptor; Anxiolytic; In silico; In vivo; Pharmacology; Chemistry; Receptor; Neuroscience; Biology; Biochemistry; Endocrinology; Daidzein; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001207976,0.000524162,0.0004846876,0.0001319451,0.0002060544,0.0003280174,0.0003316101,0.000233565,0.001944177],"category_scores_gemma":[0.0001617932,0.0001750739,0.0005884607,0.000150153,0.0001553136,0.0002165273,0.0001378891,0.0005008636,0.0002771422],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000299292,"about_ca_system_score_gemma":0.0002217206,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003977543,"about_ca_topic_score_gemma":0.005500596,"domain_scores_codex":[0.9999485,0.000009800087,0.000002548798,0.00001531269,0.00001165771,0.00001215647],"domain_scores_gemma":[0.9999551,0.00001581303,0.00001054367,0.000003046694,0.000009916032,0.000005638708],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003020041,0.0003695436,0.01065169,0.001961707,0.0006916217,0.001000655,0.0001264376,0.03622235,0.9231567,0.001761144,0.001323537,0.01971449],"study_design_scores_gemma":[0.0009479833,0.004412351,0.02773632,0.0001394016,0.002440553,0.001346619,0.0004830474,0.1778685,0.7558795,0.001607538,0.02696179,0.0001764864],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9846718,0.00566282,0.005279112,0.0002374182,0.00003872089,0.00003885383,0.001697639,0.0001043088,0.002269341],"genre_scores_gemma":[0.9912966,0.003395785,0.003076937,0.0000598072,0.000005312577,0.00001375995,0.001260252,0.00001494035,0.0008765999],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003977543,"threshold_uncertainty_score":0.007908762,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1290879761252345,"score_gpt":0.4919793892356648,"score_spread":0.3628914131104303,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}