{"id":"W4402564542","doi":"10.1016/j.ebiom.2024.105316","title":"Phosphoproteomics predict response to midostaurin plus chemotherapy in independent cohorts of FLT3-mutated acute myeloid leukaemia","year":2024,"lang":"en","type":"article","venue":"EBioMedicine","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"Innovate UK","keywords":"Midostaurin; Medicine; Phosphoproteomics; Oncology; Myeloid leukaemia; Myeloid leukemia; Chemotherapy; Internal medicine; Nilotinib; Myeloid; Cancer research; Bioinformatics; Biology; Imatinib; Genetics; Kinase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002276576,0.000436315,0.001080608,0.00171302,0.00004398116,0.00003176955,0.0003834044,0.0003477481,0.0006774185],"category_scores_gemma":[0.00042853,0.0003571564,0.0001574449,0.002731987,0.0003253316,0.0001228587,0.0002055557,0.001022331,0.000146626],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002422116,"about_ca_system_score_gemma":0.002126537,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007299198,"about_ca_topic_score_gemma":0.00003872864,"domain_scores_codex":[0.9958497,0.0001574872,0.001004664,0.0008441301,0.001315673,0.0008283083],"domain_scores_gemma":[0.9978912,0.0003276844,0.0001011875,0.0008493168,0.0002229556,0.0006076825],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.04296651,0.0003194115,0.008535001,0.0008511691,0.0009266122,0.008301633,0.005429162,0.00005821137,0.877807,0.00005262526,0.03446156,0.02029105],"study_design_scores_gemma":[0.03951283,0.009070259,0.2294713,0.006357634,0.0005758889,0.002398768,0.001662707,0.01269326,0.6295802,0.0002295433,0.06727179,0.001175813],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9782566,0.001526727,0.0006705698,0.01552292,0.0004913292,0.002559688,0.0001067731,0.0002421476,0.0006232117],"genre_scores_gemma":[0.9895207,0.0008764607,0.001429507,0.001229134,0.0003605599,0.0001783356,0.0001758616,0.0001430273,0.006086363],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2482268,"threshold_uncertainty_score":0.9998881,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01074184353169834,"score_gpt":0.3045422122924583,"score_spread":0.29380036876076,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}