{"id":"W4402565617","doi":"10.1016/j.annonc.2024.08.2297","title":"LBA55 Mechanisms of acquired resistance to first-line amivantamab plus lazertinib versus osimertinib in patients with EGFR-mutant advanced non-small cell lung cancer: An early analysis from the phase III MARIPOSA study","year":2024,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre","funders":"Chugai Pharmaceutical; Amgen; Pfizer; Genentech; AstraZeneca; Daiichi Sankyo Europe; Eli Lilly and Company; Mesothelioma Applied Research Foundation","keywords":"Osimertinib; Medicine; Mutant; Acquired resistance; Lung cancer; Oncology; Cancer research; Internal medicine; Cancer; Epidermal growth factor receptor; Genetics; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001269316,0.0006065108,0.001470283,0.0003623912,0.0002212826,0.001401907,0.0005740394,0.0004766429,0.002177196],"category_scores_gemma":[0.0008496799,0.0003946612,0.002503471,0.0003807091,0.0004488078,0.0006993245,0.0003073725,0.001531553,0.0003775798],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001424102,"about_ca_system_score_gemma":0.0008686102,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001022872,"about_ca_topic_score_gemma":0.003059017,"domain_scores_codex":[0.9995553,0.0001522218,0.00002632843,0.0000794541,0.00006793089,0.0001187693],"domain_scores_gemma":[0.9995868,0.0001162744,0.000112228,0.00003936003,0.00003009549,0.0001151772],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.467971,0.00907204,0.1608288,0.0009795153,0.01168829,0.0004255041,0.0002476017,0.005328886,0.06576557,0.001070442,0.005302122,0.2713204],"study_design_scores_gemma":[0.1806533,0.2294629,0.5211611,0.0002768928,0.02035455,0.001927064,0.0004623507,0.01068984,0.0195026,0.001736755,0.01357542,0.0001971699],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951197,0.003179892,0.0001130861,0.0002425875,0.00004770712,0.00007862326,0.0003948914,0.00002852365,0.000795099],"genre_scores_gemma":[0.997422,0.0008967431,0.0001648673,0.00021534,0.00004241108,0.00005264943,0.0007133989,0.00000976205,0.0004828834],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002177196,"threshold_uncertainty_score":0.01033264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02863594346829935,"score_gpt":0.3866559773268554,"score_spread":0.3580200338585561,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}