{"id":"W4402574883","doi":"10.1097/prs.0000000000011748","title":"Predictive Modeling of Immunogenicity to Botulinum Toxin A Treatments for Glabellar Lines","year":2024,"lang":"en","type":"article","venue":"Plastic & Reconstructive Surgery","topic":"Botulinum Toxin and Related Neurological Disorders","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Immunogenicity; Logistic regression; Medicine; Cervical dystonia; Clinical trial; Botulinum toxin; Immune system; Internal medicine; Immunology; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001993569,0.0002786385,0.000673705,0.0003213378,0.00007320206,0.00001795043,0.00006952781,0.0002390446,0.00008518777],"category_scores_gemma":[0.001305446,0.0002142685,0.0004515639,0.0004588042,0.0001441254,0.00008469578,0.00004323414,0.0002650318,0.00003143993],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007676663,"about_ca_system_score_gemma":0.0002458872,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001630132,"about_ca_topic_score_gemma":0.000002298143,"domain_scores_codex":[0.9982014,0.00005478908,0.0005955023,0.0005497396,0.0002133823,0.0003852187],"domain_scores_gemma":[0.9964702,0.002866279,0.00007653742,0.0001954451,0.000194078,0.0001975006],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.05844559,0.005576126,0.1314749,0.0061793,0.03320503,0.001447633,0.004623365,0.0555097,0.2287794,0.002862084,0.007365448,0.4645315],"study_design_scores_gemma":[0.005287347,0.004763396,0.01316448,0.004166227,0.004600612,0.0009313021,0.001171421,0.9227818,0.03032823,0.009922773,0.00145184,0.001430529],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9735148,0.001747038,0.02089426,0.0002487024,0.001740051,0.001007431,0.0002629914,0.000160532,0.0004241867],"genre_scores_gemma":[0.9973024,0.0003894047,0.001651994,0.000111927,0.0001394133,0.0001811313,0.00004131037,0.00004383734,0.0001386332],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8672721,"threshold_uncertainty_score":0.8737618,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0298729578208104,"score_gpt":0.2690836143424694,"score_spread":0.239210656521659,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}