{"id":"W4402578899","doi":"10.1097/01.hjh.0001063548.35277.58","title":"P169 VEGF INHIBITION-INDUCED PARP OVERACTIVATION LEADS TO ENDOTHELIAL DYSFUNCTION AND INFLAMMATION: ROLE OF SIRTUIN 1 SIGNALLING","year":2024,"lang":"en","type":"article","venue":"Journal of Hypertension","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Medicine; Inflammation; Poly ADP ribose polymerase; Sirtuin; Endothelial dysfunction; Cancer research; VEGF receptors; Sirtuin 1; Cell biology; Immunology; Internal medicine; Downregulation and upregulation; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001904564,0.0004164278,0.0005500894,0.0002324487,0.0002512833,0.0005484756,0.0002495504,0.0006312777,0.007574739],"category_scores_gemma":[0.0002191184,0.0002341497,0.0007205523,0.0002394078,0.0003455616,0.0004042037,0.0002211094,0.001613131,0.001152228],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002704263,"about_ca_system_score_gemma":0.0002742169,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005068907,"about_ca_topic_score_gemma":0.000493096,"domain_scores_codex":[0.999712,0.00004287292,0.00002582028,0.00006823804,0.00007571538,0.0000753103],"domain_scores_gemma":[0.9998858,0.00001249734,0.00003947008,0.00000939841,0.00001474895,0.00003808542],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002117284,0.0002121882,0.0007433472,0.0005744826,0.00006937161,0.0006962296,0.00006691166,0.0001238271,0.9853002,0.0006373228,0.001071185,0.008387543],"study_design_scores_gemma":[0.0003567098,0.002378757,0.0211434,0.00006657821,0.0001174069,0.003557041,0.0002543163,0.001536932,0.9481355,0.0009323722,0.02148378,0.00003719156],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9417676,0.03304416,0.007897902,0.002032718,0.001111721,0.0001148168,0.003055137,0.0004610348,0.01051491],"genre_scores_gemma":[0.9854528,0.005506408,0.0017099,0.0003755198,0.0001061309,0.00007526421,0.001287421,0.00003328087,0.005453208],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007574739,"threshold_uncertainty_score":0.02534002,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01120884902076611,"score_gpt":0.2203778215764869,"score_spread":0.2091689725557208,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}