{"id":"W4402580375","doi":"10.1001/jamainternmed.2024.4606","title":"Reaction Risk to Direct Penicillin Challenges","year":2024,"lang":"en","type":"review","venue":"JAMA Internal Medicine","topic":"Drug-Induced Adverse Reactions","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Impact","funders":"","keywords":"Medicine; Penicillin; Intensive care medicine; Microbiology; Antibiotics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0009296585,0.0008248701,0.00314829,0.001355933,0.00006206073,0.00003272881,0.000335586,0.0006018903,0.0001108075],"category_scores_gemma":[0.002776943,0.0005236429,0.0008307168,0.0006721905,0.0001015652,0.0001211659,0.0001779966,0.002832388,0.005292166],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001122183,"about_ca_system_score_gemma":0.0002910982,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001135281,"about_ca_topic_score_gemma":0.0001351043,"domain_scores_codex":[0.9961654,0.0002053587,0.001211112,0.001056514,0.0008629826,0.0004986399],"domain_scores_gemma":[0.99699,0.0006429541,0.0005067525,0.0009747692,0.0002050651,0.0006804965],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00001800874,0.00008061249,9.156373e-7,0.01164182,0.001076652,0.0006415502,0.00029959,9.766995e-8,0.00001382615,0.00009864926,0.01004475,0.9760835],"study_design_scores_gemma":[0.0004932502,0.0002848732,0.00006311164,0.1327171,0.009040474,0.001945618,0.000215107,0.000004653311,0.000003897363,0.00003319266,0.8548634,0.0003353675],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000009223314,0.7801785,0.00001516197,0.003963047,0.004458612,0.001074232,0.00005625719,0.0003065954,0.2099384],"genre_scores_gemma":[0.0001399447,0.9697706,0.00009342152,0.0003173665,0.008184858,0.0002417931,0.000108783,0.0002145979,0.02092868],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9757482,"threshold_uncertainty_score":0.9997215,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1025553873904281,"score_gpt":0.4054116417723265,"score_spread":0.3028562543818983,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}