{"id":"W4402580959","doi":"10.1038/s44321-024-00137-8","title":"7D, a small molecule inhibits dengue infection by increasing interferons and neutralizing-antibodies via CXCL4:CXCR3:p38:IRF3 and Sirt1:STAT3 axes respectively","year":2024,"lang":"en","type":"article","venue":"EMBO Molecular Medicine","topic":"Mosquito-borne diseases and control","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Science and Engineering Research Board; Department of Science and Technology, Ministry of Science and Technology, India; Regional Centre for Biotechnology; Department of Biotechnology, Ministry of Science and Technology, India; Duke-NUS Medical School; Ottawa Hospital Research Institute","keywords":"IRF3; Dengue fever; Virology; Antibody; Neutralizing antibody; Dengue virus; STAT3; CXCR3; Chemistry; Molecular biology; Cell biology; Biology; Immunology; Immune system; Signal transduction; Innate immune system; Chemokine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005603771,0.0002516514,0.0002071907,0.000241282,0.0001144744,0.000115811,0.0001451732,0.0001608515,0.003345272],"category_scores_gemma":[0.00003785545,0.00008368806,0.0002516499,0.0001118367,0.0001100469,0.0001042801,0.0001136679,0.0004625518,0.0004301466],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001399744,"about_ca_system_score_gemma":0.0001570686,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002718704,"about_ca_topic_score_gemma":0.0008273508,"domain_scores_codex":[0.9999709,0.000004228749,0.000002749852,0.000005738842,0.000007918281,0.000008548942],"domain_scores_gemma":[0.9999869,0.000001832343,0.000002906711,0.000001064008,0.000002630662,0.000004728973],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007340478,0.0002390901,0.0002627339,0.0004118436,0.00004166202,0.00005721043,0.00001498233,0.0002221262,0.9787539,0.0003837511,0.0008854898,0.01799331],"study_design_scores_gemma":[0.0005900434,0.004173038,0.005870448,0.00004836916,0.00009919966,0.0003903076,0.00003709324,0.001208247,0.9559156,0.0001959154,0.03145278,0.0000188722],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9483697,0.02664481,0.006897917,0.0006578898,0.000336121,0.0002446665,0.003304353,0.0005446438,0.01299996],"genre_scores_gemma":[0.9770409,0.008785141,0.004385377,0.0003560229,0.00004437163,0.0001414251,0.002263017,0.00002261851,0.006961133],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003345272,"threshold_uncertainty_score":0.01119107,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01043054904229831,"score_gpt":0.2749007674520887,"score_spread":0.2644702184097904,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}