{"id":"W4402581750","doi":"10.1101/cshperspect.a041598","title":"Autoantigen-Specific Immunotherapies for the Prevention and Treatment of Type 1 Diabetes","year":2024,"lang":"en","type":"review","venue":"Cold Spring Harbor Perspectives in Medicine","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Immune system; Immunotherapy; Immunology; Bystander effect; Type 1 diabetes; Medicine; Autoimmunity; Immune tolerance; Antigen; Diabetes mellitus; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007835563,0.0009164001,0.001088773,0.00199647,0.000253188,0.0009896561,0.0008502424,0.001112648,0.004611502],"category_scores_gemma":[0.0006125995,0.0002551275,0.0004973272,0.001325635,0.0004658521,0.0009884711,0.000796383,0.00306307,0.003467212],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005482456,"about_ca_system_score_gemma":0.0006087683,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007474479,"about_ca_topic_score_gemma":0.001812883,"domain_scores_codex":[0.9998102,0.00003515445,0.00001788732,0.00002456487,0.00008648624,0.00002571944],"domain_scores_gemma":[0.9997918,0.00007434632,0.00002778313,0.000008216845,0.00006451926,0.00003343307],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001308454,0.0001529552,0.00008536219,0.006123655,0.00008425793,0.0001814311,0.00003704898,0.0003143103,0.003504449,0.004926939,0.04086665,0.9435921],"study_design_scores_gemma":[0.00004907811,0.0001306497,0.0003516863,0.001523663,0.00006525665,0.0005863985,0.00002603632,0.00009170895,0.0006517011,0.001814905,0.9946952,0.00001366709],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001711762,0.99701,0.0002325775,0.0003917858,0.0005328241,0.0000116448,0.00002255937,0.0000174075,0.001609963],"genre_scores_gemma":[0.0008837178,0.9966808,0.0003636815,0.000414234,0.0002401024,0.00001377092,0.00003913501,0.000003293853,0.001361203],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004611502,"threshold_uncertainty_score":0.01542699,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02988782560318845,"score_gpt":0.3223256401080674,"score_spread":0.2924378145048789,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}