{"id":"W4402596350","doi":"10.1101/2024.09.17.613365","title":"Type-II kinase inhibitors that target Parkinson’s Disease-associated LRRK2","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of California, San Diego; National Institutes of Health; European Federation of Pharmaceutical Industries and Associations; McGill University; Genentech; Bayer; Pfizer; Genome Canada; Michael J. Fox Foundation for Parkinson's Research","keywords":"LRRK2; Parkinson's disease; Kinase; Disease; Medicine; Pharmacology; Internal medicine; Chemistry; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001792951,0.0004838249,0.0003772606,0.000179275,0.0001806477,0.0005487786,0.0002330878,0.0002400461,0.002059428],"category_scores_gemma":[0.0001494075,0.0001433494,0.0002597031,0.0001702559,0.0001898186,0.0002241563,0.0002458612,0.0005204203,0.0007632272],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000322825,"about_ca_system_score_gemma":0.0003831279,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004231012,"about_ca_topic_score_gemma":0.00121382,"domain_scores_codex":[0.9999017,0.00001267655,0.000006689429,0.00002013601,0.00003768987,0.00002121519],"domain_scores_gemma":[0.9999539,0.000006491336,0.00001408477,0.000004858774,0.000008053951,0.00001260449],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003461111,0.0002085904,0.001109175,0.0002580517,0.00006971368,0.0002859185,0.00006856451,0.00547344,0.9523027,0.00321866,0.002632285,0.03402673],"study_design_scores_gemma":[0.0001748854,0.0009023398,0.001543132,0.00001703,0.00005976756,0.000697201,0.00002770584,0.005077593,0.9604191,0.0006002871,0.03046145,0.00001949922],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8907754,0.02273924,0.04618873,0.0009361281,0.0003379811,0.0004349931,0.001501632,0.0007823352,0.03630352],"genre_scores_gemma":[0.9562986,0.008526391,0.02134214,0.0002972245,0.00005073876,0.0001699643,0.0010537,0.0001101554,0.01215114],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002059428,"threshold_uncertainty_score":0.006889462,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01717930223603393,"score_gpt":0.2355277893196969,"score_spread":0.218348487083663,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}