{"id":"W4402600892","doi":"10.1038/s42003-024-06882-3","title":"Activation of the NLRP1B inflammasome by caspase-8","year":2024,"lang":"en","type":"article","venue":"Communications Biology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Government of Canada","keywords":"Inflammasome; Chemistry; Caspase 1; Cell biology; Biology; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001190913,0.0000768969,0.00007305678,0.00003274179,0.0001047635,0.000009708959,0.0006646147,0.0001228249,0.00001818721],"category_scores_gemma":[0.00008219003,0.00005722762,0.00007932595,0.0001539737,0.0002898907,0.000004199904,0.0003664585,0.0001151122,0.00001320612],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009083613,"about_ca_system_score_gemma":0.00006840329,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002862002,"about_ca_topic_score_gemma":0.00002159199,"domain_scores_codex":[0.9994319,0.0001254194,0.0001763085,0.0001291854,0.00002958161,0.0001075723],"domain_scores_gemma":[0.9986796,0.0000373656,0.00005132606,0.001164955,0.00005418061,0.00001259777],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000006992885,0.00002535677,0.001468965,0.00001009976,0.00004945148,2.227013e-8,0.00007302835,0.000003612456,0.97911,0.006231249,0.006469696,0.006551504],"study_design_scores_gemma":[0.0001087205,0.00005778862,0.0007739663,0.00001695928,0.00001181402,0.000002529827,0.00007730816,0.0001188105,0.390476,0.0006534864,0.6076178,0.00008488379],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9675673,0.01484762,0.0009586215,0.005314092,0.0002755303,0.0002895034,0.00006505451,0.00003218974,0.01065004],"genre_scores_gemma":[0.9973491,0.001109452,0.0001422246,0.0001737075,0.00002804439,0.00003743013,0.000420845,0.00001080925,0.0007283592],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6011481,"threshold_uncertainty_score":0.2333675,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01073004860444716,"score_gpt":0.2736738200626695,"score_spread":0.2629437714582224,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}