{"id":"W4402600892","doi":"10.1038/s42003-024-06882-3","title":"Activation of the NLRP1B inflammasome by caspase-8","year":2024,"lang":"en","type":"article","venue":"Communications Biology","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Government of Canada","keywords":"Inflammasome; Chemistry; Caspase 1; Cell biology; Biology; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002230601,0.0004258285,0.0002466332,0.000317599,0.0001858511,0.0003573174,0.0002025867,0.0003905112,0.002192146],"category_scores_gemma":[0.0002778547,0.0001619196,0.0003252212,0.0001715315,0.0002407177,0.0004143426,0.0003937959,0.000652162,0.0009646905],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003611284,"about_ca_system_score_gemma":0.0001905036,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001232229,"about_ca_topic_score_gemma":0.0001012845,"domain_scores_codex":[0.99975,0.00005484042,0.00002840604,0.0000554253,0.0000646345,0.00004675395],"domain_scores_gemma":[0.9998274,0.00001611743,0.00007756785,0.00001925216,0.00003271407,0.00002698083],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002280406,0.00002919187,0.0004394799,0.0000942281,0.000009258025,0.0001478645,0.00002496565,0.00009237674,0.9944152,0.0002852392,0.0000971862,0.004136928],"study_design_scores_gemma":[0.00009679205,0.0005922626,0.008617115,0.0000442848,0.00001533098,0.002102362,0.00006993705,0.001928343,0.9757988,0.00117025,0.009550428,0.0000140696],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9482157,0.01896014,0.0241751,0.00095381,0.0001589486,0.00009118708,0.000619799,0.0003260512,0.006499229],"genre_scores_gemma":[0.9847792,0.003941863,0.007689285,0.0001225601,0.00003550337,0.00006427162,0.0004142713,0.00001501996,0.0029381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002192146,"threshold_uncertainty_score":0.007333457,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01073004860444716,"score_gpt":0.2736738200626695,"score_spread":0.2629437714582224,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}