{"id":"W4402611872","doi":"10.1097/01.hjh.0001062604.74851.9a","title":"O65 SARCOPLASMIC CALCIUM ATPASE (SERCA) PROTEOLYSIS BY MATRIX METALLOPROTEINASE (MMP)-2 CONTRIBUTES TO VASCULAR DYSFUNCTION IN EARLY HYPERTENSION","year":2024,"lang":"en","type":"article","venue":"Journal of Hypertension","topic":"Biological Research and Disease Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Medicine; Proteolysis; Matrix metalloproteinase; SERCA; Internal medicine; Sarcoplasm; Calcium; ATPase; Endocrinology; Cardiology; Enzyme; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001895079,0.0003760934,0.0003634995,0.0002725171,0.0001774407,0.0003188483,0.0001322307,0.0002878178,0.001818875],"category_scores_gemma":[0.0001165979,0.0001536934,0.0003351402,0.0001487238,0.0002474166,0.0001842415,0.0001901492,0.000530065,0.0003518085],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000137874,"about_ca_system_score_gemma":0.0001587166,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003357316,"about_ca_topic_score_gemma":0.0004790972,"domain_scores_codex":[0.9998937,0.00001334106,0.00000954901,0.00002600827,0.00002249639,0.00003488635],"domain_scores_gemma":[0.9997764,0.00001426793,0.00007886925,0.00001206255,0.00002426703,0.00009410318],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007718157,0.0001281363,0.005395073,0.0001245271,0.00002475911,0.0003612752,0.00002703336,0.00001760079,0.9904429,0.00004706463,0.0001770693,0.002482572],"study_design_scores_gemma":[0.0002122099,0.00349273,0.4836755,0.0001081895,0.0003445449,0.006004682,0.0002949723,0.001578615,0.4991772,0.0003912155,0.004698165,0.0000220715],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908557,0.006360084,0.001256037,0.0002588619,0.00008411655,0.00001833783,0.0001791448,0.00006452448,0.0009232544],"genre_scores_gemma":[0.9940959,0.003033624,0.0006159981,0.00007181608,0.0001006975,0.00001918365,0.0002174979,0.000007727836,0.001837571],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001818875,"threshold_uncertainty_score":0.00608474,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02039452817710623,"score_gpt":0.2714053524899439,"score_spread":0.2510108243128377,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}