{"id":"W4402625163","doi":"10.1016/j.bja.2024.06.048","title":"Propofol binds and inhibits skeletal muscle ryanodine receptor 1","year":2024,"lang":"en","type":"article","venue":"British Journal of Anaesthesia","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of General Medical Sciences; National Institutes of Health; University of Wisconsin-Madison; Foundation for Anesthesia Education and Research","keywords":"Ryanodine receptor; Propofol; Skeletal muscle; Receptor; Chemistry; Pharmacology; Biophysics; Internal medicine; Medicine; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001307067,0.0002723586,0.0002756907,0.0001173192,0.0001771467,0.0002828729,0.000257781,0.0003239203,0.002438972],"category_scores_gemma":[0.0003386829,0.0001555626,0.0003261605,0.00006529649,0.0002393037,0.0001593694,0.0003017975,0.0003213685,0.0006740151],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003080034,"about_ca_system_score_gemma":0.0002706549,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001168161,"about_ca_topic_score_gemma":0.001028178,"domain_scores_codex":[0.9997957,0.00003505003,0.000009522786,0.00002944345,0.00007395478,0.00005622032],"domain_scores_gemma":[0.9998673,0.00003762942,0.00005717155,0.000007983028,0.00001161457,0.00001829609],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004927962,0.00005798034,0.00112421,0.0003314952,0.00004289938,0.0001491061,0.00003126952,0.001018446,0.9843189,0.0006119924,0.0004429128,0.01137785],"study_design_scores_gemma":[0.0001714211,0.00166891,0.02252237,0.0000669151,0.00009581014,0.001106974,0.00007739217,0.008675386,0.9530566,0.0004077851,0.01212727,0.00002319882],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9845865,0.005876089,0.004147484,0.0004674898,0.00005291686,0.00003538711,0.0002150842,0.0001387835,0.004480158],"genre_scores_gemma":[0.9948269,0.002208896,0.0008410914,0.0001052666,0.00001428381,0.00001703763,0.0001975093,0.00001579613,0.001773332],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002438972,"threshold_uncertainty_score":0.008159161,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007167893443018737,"score_gpt":0.221638724275083,"score_spread":0.2144708308320643,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}