{"id":"W4402625492","doi":"10.1101/2024.09.13.612935","title":"Pharmacological Inhibition of Epac1 Protects against Pulmonary Fibrosis by Blocking FoxO3a Neddylation","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut universitaire de cardiologie et de pneumologie de Québec","funders":"CHIST-ERA; National Heart, Lung, and Blood Institute; National Institutes of Health; Université de Toulouse; Agence Nationale de la Recherche; American Thoracic Society; Fondation pour la Recherche Médicale; Institut National de la Santé et de la Recherche Médicale; American Heart Association","keywords":"Neddylation; Blocking (statistics); Pulmonary fibrosis; Medicine; Pharmacology; Chemistry; Fibrosis; Computer science; Internal medicine; Ubiquitin; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002202701,0.0002929404,0.0004426244,0.0002816442,0.0002128932,0.0002127686,0.0002321559,0.0003181672,0.00274032],"category_scores_gemma":[0.0001117102,0.0001422372,0.0004829673,0.000163414,0.0003724147,0.0001925928,0.0001712721,0.0009498431,0.0003716828],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002564056,"about_ca_system_score_gemma":0.0003497579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006352085,"about_ca_topic_score_gemma":0.000973727,"domain_scores_codex":[0.9998946,0.00001413014,0.00001179485,0.00002249487,0.0000183658,0.00003861276],"domain_scores_gemma":[0.9999222,0.00001011363,0.00002109647,0.000009521965,0.000009118507,0.00002804772],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001927438,0.0003340351,0.0002864979,0.0001751405,0.00002572,0.00004492467,0.00002193629,0.0001506637,0.9922477,0.0002688315,0.0003743917,0.004142695],"study_design_scores_gemma":[0.0004724165,0.003043266,0.005141267,0.00003392985,0.00006285914,0.000203764,0.00006104707,0.001909138,0.9827766,0.0001639415,0.006119045,0.00001265827],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885169,0.003900128,0.002927779,0.0003449262,0.000129515,0.00008396108,0.0009462031,0.0002676875,0.00288287],"genre_scores_gemma":[0.9923403,0.001634211,0.00249243,0.0001395591,0.00002470768,0.0001167305,0.0009251263,0.00002725936,0.002299545],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00274032,"threshold_uncertainty_score":0.009167314,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01148926806299226,"score_gpt":0.23905883293226,"score_spread":0.2275695648692678,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}