{"id":"W4402632406","doi":"10.1038/s42003-024-06829-8","title":"Fingerprints of brain disease: connectome identifiability in Alzheimer’s disease","year":2024,"lang":"en","type":"article","venue":"Communications Biology","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; Canadian Institutes of Health Research; Avid Radiopharmaceuticals; Horizon 2020 Framework Programme; Genentech; National Institutes of Health; IXICO; H. Lundbeck A/S; Servier; Siemens Healthineers; Centre d'Imagerie BioMédicale; Centre Hospitalier Universitaire Vaudois; Fondation Segré; Université de Genève; Alzheimer's Association; Hôpitaux Universitaires de Genève; Eisai; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; École Polytechnique Fédérale de Lausanne; Novo Nordisk; Northern California Institute for Research and Education; Université de Lausanne; Ministero della Salute; BioClinica; Biogen; Pfizer; Novartis Pharmaceuticals Corporation; University of Southern California; U.S. Department of Defense; Eli Lilly and Company; Bristol-Myers Squibb; Meso Scale Diagnostics; National Science Foundation","keywords":"Connectome; Disease; Neuroscience; Identifiability; Fingerprint (computing); Cognition; Alzheimer's disease; Human Connectome Project; Neuroimaging; Psychology; Functional connectivity; Medicine; Computer science; Artificial intelligence; Machine learning; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001292866,0.0002226606,0.0003166844,0.001739676,0.0002396363,0.0006711896,0.0002375433,0.0004040901,0.001176884],"category_scores_gemma":[0.008512059,0.0001706849,0.0001731296,0.001316396,0.000760609,0.001411175,0.0005759175,0.0006374439,0.00008552754],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002562643,"about_ca_system_score_gemma":0.0002139224,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009423111,"about_ca_topic_score_gemma":0.001369258,"domain_scores_codex":[0.9996866,0.0001292019,0.00001708081,0.00008680276,0.00005316499,0.00002721928],"domain_scores_gemma":[0.9970832,0.001506728,0.0007744424,0.000384212,0.0001065155,0.0001449045],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001350811,0.0001590088,0.5214254,0.0006354096,0.0008569027,0.000701017,0.002412858,0.02460154,0.09416326,0.0339436,0.003178185,0.316572],"study_design_scores_gemma":[0.00002106816,0.0001857466,0.8438483,0.0002034882,0.0001679239,0.001756091,0.0007397953,0.03339427,0.007800342,0.1087875,0.003020013,0.00007541948],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9684911,0.003847255,0.02370493,0.00139512,0.0000254329,0.00001024607,0.0005905554,0.00005935518,0.001875996],"genre_scores_gemma":[0.9954601,0.0006015742,0.003569667,0.00005328481,0.0000303056,0.000007168835,0.0001367287,0.00000871065,0.0001325853],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001739676,"threshold_uncertainty_score":0.006837428,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1180393750505924,"score_gpt":0.3806276054226392,"score_spread":0.2625882303720468,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}