{"id":"W4402636275","doi":"10.1007/s00238-024-02239-5","title":"The aging paradox: integrating biological, genetic, epigenetic, and aesthetic insights into skin aging and non-surgical interventions","year":2024,"lang":"en","type":"article","venue":"European Journal of Plastic Surgery","topic":"Skin Protection and Aging","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"Medicine; Plastic surgery; Epigenetics; Psychological intervention; Skin Aging; Surgery; Genetics; Biology; Dermatology; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001476011,0.0001698501,0.0003082013,0.0002941658,0.000278475,0.0002433181,0.00007647132,0.00002639683,0.00002725206],"category_scores_gemma":[0.0007846155,0.0000975656,0.0002651063,0.0002166977,0.0002226267,0.00007379412,0.0000841237,0.000515462,0.00001416618],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002687051,"about_ca_system_score_gemma":0.00005297739,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002945622,"about_ca_topic_score_gemma":0.000001350055,"domain_scores_codex":[0.9982169,0.0004388264,0.0007382547,0.0002103726,0.0001885326,0.0002071163],"domain_scores_gemma":[0.9970728,0.002355028,0.0001907982,0.0001069796,0.00007818109,0.00019617],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0001744412,0.0001198621,0.03258574,0.0004587695,0.0003718289,0.01101403,0.003348341,0.00006471427,0.003261906,0.0002204538,0.001273719,0.9471062],"study_design_scores_gemma":[0.003238038,0.002037973,0.7410433,0.03704837,0.0009370648,0.0464406,0.007253189,0.01396551,0.002060012,0.001286012,0.1434659,0.001224031],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9571416,0.02704028,0.01352662,0.0007464716,0.001190772,0.00007899421,3.365051e-7,0.00003344339,0.0002415144],"genre_scores_gemma":[0.9950875,0.003657175,0.0006870556,0.00005057028,0.0004332184,0.000001808713,7.34161e-7,0.00002842261,0.00005351506],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9458821,"threshold_uncertainty_score":0.397861,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02762405265558832,"score_gpt":0.2764960543792883,"score_spread":0.2488720017236999,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}