{"id":"W4402638771","doi":"10.1200/jco.23.02018","title":"Randomized Phase III SIERRA Trial of <sup>131</sup> I-Apamistamab Before Allogeneic Hematopoietic Cell Transplantation Versus Conventional Care for Relapsed/Refractory AML","year":2024,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; Princess Margaret Cancer Centre; University of Ottawa","funders":"National Center for Advancing Translational Sciences; Sanofi Pasteur; Pharmacyclics; Genentech; MorphoSys; Swedish Orphan Biovitrum; Ministry of Minority Affairs; Astellas Pharma; MacroGenics; Cardinal Health; Syndax Pharmaceuticals; Seagen; CTI Biopharma; BeiGene; Astex Pharmaceuticals; Therakos; TG Therapeutics; Ipsen; Jazz Pharmaceuticals; Y-mAbs Therapeutics; Fred Hutchinson Cancer Research Center; Ironwood Pharmaceuticals, Incorporated; Taiho Pharmaceutical; Case Western Reserve University; MEI Pharma; Karyopharm Therapeutics; Celgene; Regeneron Pharmaceuticals; CSL Behring; Abbott Laboratories; Actinium Pharmaceuticals; National Cancer Institute; Servier; Gilead Sciences; GlaxoSmithKline; Bristol-Myers Squibb; Eli Lilly and Company; AstraZeneca; Spectrum Pharmaceuticals; Amgen; Moderna; Incyte; Pfizer; Sanofi","keywords":"Medicine; Transplantation; Hazard ratio; Internal medicine; Regimen; Surgery; Population; Refractory (planetary science); Clinical endpoint; Salvage therapy; Hematopoietic stem cell transplantation; Chemotherapy regimen; Gastroenterology; Chemotherapy; Randomized controlled trial; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001487907,0.001263109,0.001777404,0.0003135029,0.000360584,0.001101685,0.0007746961,0.001029791,0.005438847],"category_scores_gemma":[0.001200143,0.0004324773,0.001498217,0.0002719334,0.0008049641,0.0006499426,0.0004246797,0.002798663,0.0008704524],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007089627,"about_ca_system_score_gemma":0.0012849,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001161856,"about_ca_topic_score_gemma":0.003226888,"domain_scores_codex":[0.9995459,0.0002779936,0.00002087085,0.00006812748,0.00003028662,0.00005681114],"domain_scores_gemma":[0.9993021,0.0001634833,0.0001935246,0.00005745682,0.00003732018,0.0002460207],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9701818,0.0059717,0.0006155372,0.000563416,0.0006244802,0.00003976513,0.00004562096,0.0005158188,0.004032405,0.0002429032,0.001401918,0.01576455],"study_design_scores_gemma":[0.9505561,0.04632448,0.001010809,0.00003103073,0.0003333786,0.00003238177,0.00001657151,0.000297097,0.0003508677,0.0001666174,0.0008715861,0.00000914919],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9748706,0.006118678,0.00100456,0.001164575,0.000869185,0.008572014,0.002090136,0.0002646775,0.005045695],"genre_scores_gemma":[0.9735602,0.003508026,0.002760512,0.002943452,0.0007356266,0.008183098,0.00242003,0.00004911284,0.00584004],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005438847,"threshold_uncertainty_score":0.01819474,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07114274363281915,"score_gpt":0.4259744765300983,"score_spread":0.3548317328972792,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}