{"id":"W4402642184","doi":"10.3390/curroncol31090415","title":"Doxycycline Plus Bortezomib-Containing Regimens for the Treatment of Light-Chain Amyloidosis in the Frontline Setting: Experience from the Amyloidosis Program of Calgary","year":2024,"lang":"en","type":"article","venue":"Current Oncology","topic":"Amyloidosis: Diagnosis, Treatment, Outcomes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research; University of Calgary","funders":"","keywords":"Medicine; Doxycycline; Bortezomib; AL amyloidosis; Amyloidosis; Internal medicine; Retrospective cohort study; Surgery; Gastroenterology; Oncology; Multiple myeloma; Immunoglobulin light chain; Immunology; Antibiotics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000921737,0.000358523,0.0004556337,0.0002655709,0.0004229173,0.0005902213,0.0004646303,0.0002423758,0.0007097759],"category_scores_gemma":[0.001426236,0.0001407809,0.000291349,0.000546214,0.0003668474,0.0002312252,0.0004247597,0.0006582864,0.00016442],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001026137,"about_ca_system_score_gemma":0.001115255,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005467078,"about_ca_topic_score_gemma":0.01303429,"domain_scores_codex":[0.9995149,0.0001819378,0.00003553928,0.0000963999,0.00009170191,0.00007941794],"domain_scores_gemma":[0.9986898,0.0004030119,0.0002278995,0.00006610851,0.0001422951,0.0004709777],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.01071268,0.006409494,0.1912771,0.001060985,0.0005297951,0.003933472,0.002105575,0.001274065,0.02295304,0.0001817012,0.0040137,0.7555484],"study_design_scores_gemma":[0.00627468,0.05758198,0.8843293,0.0005509567,0.00074381,0.009195087,0.0009822206,0.001057626,0.007710373,0.000106795,0.03141328,0.00005395433],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9816933,0.01562712,0.0003066482,0.0003993515,0.00002983085,0.0001610764,0.0001044178,0.00001133842,0.001666836],"genre_scores_gemma":[0.9804333,0.01633983,0.001507873,0.0005592115,0.0001751829,0.0000613055,0.0002701559,0.00001680965,0.0006363269],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9945329,"threshold_uncertainty_score":0.01087052,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05679446509108542,"score_gpt":0.390263158142941,"score_spread":0.3334686930518556,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}