{"id":"W4402643366","doi":"10.1016/s1474-4422(24)00369-7","title":"Global, regional, and national burden of stroke and its risk factors, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021","year":2024,"lang":"en","type":"article","venue":"The Lancet Neurology","topic":"Acute Ischemic Stroke Management","field":"Medicine","cited_by":1221,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Cilag; Precursory Research for Embryonic Science and Technology; Japan Science and Technology Agency; Novartis Pharma; Allergan; National Institutes of Health; European Stroke Organisation; Esperion Therapeutics; National Science and Technology Council; DSM Nutritional Products; Intas Pharmaceuticals; Lilly Deutschland; National Research, Development and Innovation Office; National Health and Medical Research Council; Neuraxpharm; Novo Nordisk Pharma; Ministry of Science and ICT, South Korea; Medical Research Council; African Academy of Sciences; Servier; Istituto Auxologico Italiano; University of Jordan; Novo Nordisk; Eisai; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Ministero della Salute; Generalitat de Catalunya; Ministry of Education, Culture, Sports, Science and Technology; Amryt Pharma; Australian Academy of Science; Johns Hopkins University; Amarin Corporation; Cardinal Health; Daiichi Sankyo Europe; Agios Pharmaceuticals; Regeneron Pharmaceuticals; Fondazione Cariplo; Fresenius Medical Care North America; Deutsche Forschungsgemeinschaft; Alzheimer's Association; Global Brain Health Institute; Idorsia Pharmaceuticals; H. Lundbeck A/S; International Hepato-Pancreato-Biliary Association; Government of Canada; Ultragenyx Pharmaceutical; Canadian Institutes of Health Research; Italfarmaco; Korean Diabetes Association; European Commission; AstraZeneca; International Atomic Energy Agency; Alexion Pharmaceuticals; National Research Foundation of Korea; Biogen; King Saud University; Bristol-Myers Squibb; Teva Pharmaceutical Industries; American Heart Association; Moderna; Bill and Melinda Gates Foundation; Pfizer; Amicus Therapeutics; Casen Recordati; Alexander von Humboldt-Stiftung; Japan Society for the Promotion of Science; Swedish Orphan Biovitrum; Astellas Pharma; Bayer; Cardiff University; U.S. Department of Defense; Eli Lilly and Company; AOSpine; Danone; American Diabetes Association; Sociedad Madrileña de Nefrología; National Research Foundation; Amgen; International Society of Travel Medicine; National Cerebral and Cardiovascular Center; Sanofi","keywords":"Burden of disease; Stroke (engine); Disease; Medicine; Environmental health; Internal medicine; Engineering","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01201136,0.001064363,0.003584386,0.007328573,0.0003873249,0.001026447,0.0008088818,0.0008310732,0.001191551],"category_scores_gemma":[0.01600119,0.0009273819,0.01232626,0.01103207,0.0004454729,0.0006416998,0.001433929,0.0009126185,0.0002716128],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002228316,"about_ca_system_score_gemma":0.007419684,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.07649399,"about_ca_topic_score_gemma":0.1147883,"domain_scores_codex":[0.995532,0.001860763,0.0009347021,0.0006526588,0.0008040444,0.000215787],"domain_scores_gemma":[0.9929248,0.002575008,0.002045104,0.0005121675,0.001713888,0.0002289583],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.002542134,0.00005950759,0.5796111,0.1121836,0.1623701,0.0003967258,0.0009125237,0.00850792,0.0005384568,0.001646367,0.04061765,0.09061392],"study_design_scores_gemma":[0.001490198,0.0003949196,0.7276528,0.05431264,0.1742441,0.0007891739,0.0006796315,0.006047227,0.000352524,0.001721771,0.03213567,0.0001793601],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.1141583,0.7543515,0.006877748,0.003150909,0.0005583545,0.001011695,0.1180314,0.0002693319,0.001590849],"genre_scores_gemma":[0.6398968,0.2834475,0.01232497,0.001852261,0.0003480871,0.00307705,0.05824004,0.0001138342,0.0006994542],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.07649399,"threshold_uncertainty_score":0.1520975,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03265310704893108,"score_gpt":0.309195719158222,"score_spread":0.2765426121092909,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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