{"id":"W4402652974","doi":"10.3390/molecules29184442","title":"Synthesis, Characterization, and Biological Evaluation of N-Methyl Derivatives of Norbelladine","year":2024,"lang":"en","type":"article","venue":"Molecules","topic":"Chemical synthesis and alkaloids","field":"Chemistry","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal; Université du Québec à Trois-Rivières","funders":"Natural Sciences and Engineering Research Council of Canada; Institut national de la recherche scientifique; Université du Québec à Trois-Rivières; Université Laval","keywords":"Butyrylcholinesterase; Chemistry; Docking (animal); Biological activity; Acetylcholinesterase; Biochemistry; Methylation; Myeloid leukemia; Cytotoxicity; Enzyme; Stereochemistry; Pharmacology; Biology; Gene; Medicine; In vitro; Cancer research; Aché","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001136134,0.0002676532,0.0001584572,0.0001407019,0.0001277573,0.0001365032,0.0001879174,0.0001704972,0.0009512705],"category_scores_gemma":[0.000183429,0.00007410534,0.0001711167,0.0001667494,0.0001029879,0.0002197999,0.0001431775,0.0003324118,0.0002639279],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001800177,"about_ca_system_score_gemma":0.0002128459,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008251419,"about_ca_topic_score_gemma":0.002104556,"domain_scores_codex":[0.9999527,0.000007832367,0.000004089675,0.00001016988,0.0000157855,0.000009547816],"domain_scores_gemma":[0.9999231,0.000009911082,0.0000186751,0.00001010613,0.00002291886,0.00001521556],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001316646,0.00004654839,0.0002683479,0.0002258654,0.00001326308,0.0001319017,0.00005406818,0.0004157919,0.9926404,0.0001765259,0.00006562717,0.005829908],"study_design_scores_gemma":[0.00002488062,0.0006990408,0.001804755,0.00002146779,0.00003019337,0.0002404991,0.00005073029,0.0005199931,0.9878108,0.00007391744,0.008712603,0.00001127673],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9796205,0.007055409,0.006612374,0.0001290919,0.00003983897,0.0001244405,0.0009551172,0.00005566961,0.005407574],"genre_scores_gemma":[0.9871105,0.004248012,0.00443357,0.00005358464,0.00001005198,0.00003425576,0.0007092062,0.00002400724,0.003376883],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009512705,"threshold_uncertainty_score":0.003182292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0276573218462842,"score_gpt":0.2699158775862064,"score_spread":0.2422585557399222,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}