{"id":"W4402652974","doi":"10.3390/molecules29184442","title":"Synthesis, Characterization, and Biological Evaluation of N-Methyl Derivatives of Norbelladine","year":2024,"lang":"en","type":"article","venue":"Molecules","topic":"Chemical synthesis and alkaloids","field":"Chemistry","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal; Université du Québec à Trois-Rivières","funders":"Natural Sciences and Engineering Research Council of Canada; Institut national de la recherche scientifique; Université du Québec à Trois-Rivières; Université Laval","keywords":"Butyrylcholinesterase; Chemistry; Docking (animal); Biological activity; Acetylcholinesterase; Biochemistry; Methylation; Myeloid leukemia; Cytotoxicity; Enzyme; Stereochemistry; Pharmacology; Biology; Gene; Medicine; In vitro; Cancer research; Aché","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001783772,0.00007603627,0.0001490889,0.00002722109,0.00001318302,0.00001049317,0.00005831036,0.00006435175,0.000687986],"category_scores_gemma":[0.0004206033,0.00005779043,0.00004167033,0.00008150995,0.00009776861,0.00002725946,0.00003202557,0.00003797985,0.00000174456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001071488,"about_ca_system_score_gemma":0.00001720765,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004495186,"about_ca_topic_score_gemma":2.772805e-7,"domain_scores_codex":[0.9994046,0.00002721258,0.0001900157,0.0001538149,0.0001562567,0.00006808976],"domain_scores_gemma":[0.999558,0.000204275,0.00005124582,0.00009176425,0.00007065871,0.00002407308],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000006480574,0.00002804581,0.001040017,0.0001387729,0.00003241387,4.318989e-7,0.00006243903,9.06e-7,0.9369136,0.00039235,0.000009541467,0.061375],"study_design_scores_gemma":[0.00005287154,0.000007143282,0.004792383,0.0001572318,0.00004275178,0.000001221194,0.00002910224,0.001163295,0.9924839,0.0004434283,0.0007633825,0.00006334381],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966283,0.001458899,0.0003067205,0.0001435771,0.00001255581,0.00003189976,0.00005008814,0.00002094882,0.001346949],"genre_scores_gemma":[0.9994727,0.0001986516,0.0002058694,0.000006073114,0.00003060167,0.00001365226,0.00003046941,0.000007699153,0.00003422982],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06131165,"threshold_uncertainty_score":0.7532964,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0276573218462842,"score_gpt":0.2699158775862064,"score_spread":0.2422585557399222,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}