{"id":"W4402654079","doi":"10.1136/ard-2024-226286","title":"Is a 1-year course of methotrexate in patients with arthralgia at-risk for rheumatoid arthritis cost-effective? A cost-effectiveness analysis of the randomised, placebo-controlled TREAT EARLIER trial","year":2024,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Rheumatoid Arthritis Research and Therapies","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Dutch Arthritis Association; ReumaNederland; Dutch Arthritis Society; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; ZonMw; Leids Universitair Medisch Centrum; Arthritis Society","keywords":"Medicine; Rheumatoid arthritis; Methotrexate; Placebo; Randomized controlled trial; Physical therapy; Internal medicine; Arthritis; Alternative medicine; Intensive care medicine; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007840017,0.002166801,0.006788035,0.001151849,0.000508382,0.001658965,0.001640285,0.004635024,0.01013723],"category_scores_gemma":[0.0171314,0.001186256,0.009598427,0.0008614853,0.001642487,0.002939278,0.001129836,0.004950773,0.0006007965],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002129576,"about_ca_system_score_gemma":0.001395307,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003772794,"about_ca_topic_score_gemma":0.003423308,"domain_scores_codex":[0.9917288,0.006739997,0.0003678094,0.0004315389,0.0003072146,0.0004245559],"domain_scores_gemma":[0.9876,0.0095622,0.001426714,0.0004535405,0.0002830942,0.0006744863],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.984668,0.0007060554,0.0005966153,0.001254399,0.004357804,0.0000406342,0.0000327119,0.001012109,0.000345836,0.0002148478,0.0002626439,0.006508428],"study_design_scores_gemma":[0.9317943,0.04565832,0.004188757,0.0003520915,0.01332876,0.00009512738,0.00007577167,0.002708922,0.0002400065,0.0007611856,0.0007327063,0.00006397125],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9122642,0.06526852,0.003755507,0.003343782,0.002813429,0.004052666,0.002659563,0.0002063908,0.005635869],"genre_scores_gemma":[0.9898661,0.00487119,0.001189595,0.0008988042,0.0004850362,0.0008448201,0.0006787384,0.00001739221,0.001148346],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01013723,"threshold_uncertainty_score":0.04146248,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02116046372415742,"score_gpt":0.3249224586951942,"score_spread":0.3037619949710368,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}