{"id":"W4402661929","doi":"10.1249/01.mss.0001056400.93496.a5","title":"Single-cell RNA Sequencing Revealed Fibro-adipogenic Progenitors As The Major Contributor To Radiation-induced Skeletal Muscle Fibrosis","year":2024,"lang":"en","type":"article","venue":"Medicine & Science in Sports & Exercise","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Adipogenesis; Fibrosis; Progenitor cell; Skeletal muscle; Biology; Cell biology; Cell; RNA; Cancer research; Stem cell; Internal medicine; Endocrinology; Medicine; Genetics; Gene; Mesenchymal stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001472793,0.0002708732,0.000306023,0.0003386774,0.0002056483,0.0002975383,0.0001137549,0.0002259674,0.001026951],"category_scores_gemma":[0.0001192915,0.0001256877,0.000291851,0.0002830337,0.0002004063,0.0001214017,0.0001525421,0.0003790482,0.0003787384],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001371231,"about_ca_system_score_gemma":0.0001722208,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003912428,"about_ca_topic_score_gemma":0.0009400899,"domain_scores_codex":[0.9998326,0.00001030107,0.000009047212,0.00006830753,0.0000556055,0.0000240373],"domain_scores_gemma":[0.9998916,0.00001705862,0.00003799871,0.000009659331,0.00002575262,0.00001784604],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006377543,0.000005473326,0.0009273893,0.00002723505,0.000004338438,0.00002431958,0.00001514386,0.00002818259,0.9980407,0.00001521522,0.00002614029,0.0008221445],"study_design_scores_gemma":[0.00001331223,0.0006103481,0.1959124,0.00004513885,0.0001187618,0.0006119462,0.0002633469,0.001800589,0.7954397,0.0001599576,0.005009223,0.00001537196],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9829815,0.001929556,0.008239445,0.00008757404,0.00003807467,0.00005652749,0.005071191,0.0001440248,0.001452143],"genre_scores_gemma":[0.9718185,0.002040989,0.01113227,0.0002377256,0.00002724366,0.0002015124,0.007523562,0.00006694929,0.00695127],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001026951,"threshold_uncertainty_score":0.003435493,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0102877279182377,"score_gpt":0.2587773625708277,"score_spread":0.24848963465259,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}