{"id":"W4402665105","doi":"10.1093/ecco-jcc/jjae151","title":"Outcomes of Patients With Prior Biologic Intolerance Are Better Than Those With Biologic Failure in Clinical Trials of Inflammatory Bowel Disease","year":2024,"lang":"en","type":"article","venue":"Journal of Crohn s and Colitis","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; McMaster University","funders":"","keywords":"Medicine; Internal medicine; Ustekinumab; Vedolizumab; Inflammatory bowel disease; Ulcerative colitis; Clinical trial; Post-hoc analysis; Gastroenterology; Odds ratio; Crohn's disease; Disease; Infliximab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01923249,0.0004651617,0.001432338,0.0009955064,0.0005843524,0.001726857,0.0003317262,0.0007567079,0.003082738],"category_scores_gemma":[0.0379733,0.0001809075,0.002463139,0.001194604,0.0007505961,0.001415269,0.0009856884,0.00113243,0.000198187],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003265151,"about_ca_system_score_gemma":0.0004076803,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002006124,"about_ca_topic_score_gemma":0.000435566,"domain_scores_codex":[0.9795272,0.01464484,0.00242,0.001439207,0.00138535,0.0005834246],"domain_scores_gemma":[0.9272462,0.04382682,0.02268156,0.002210318,0.001456702,0.002578538],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01936653,0.0001858954,0.9501406,0.0005375891,0.005399262,0.000154929,0.0001858378,0.0005367203,0.0004588685,0.0001332725,0.0004640771,0.02243641],"study_design_scores_gemma":[0.000853943,0.004238365,0.9883597,0.0001428505,0.002679013,0.000732012,0.0002367115,0.0007139109,0.0002868318,0.0004158657,0.001320694,0.00002015087],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9819649,0.01417955,0.0007906515,0.0006782254,0.00008374674,0.00007422289,0.0003066058,0.00001318007,0.001908877],"genre_scores_gemma":[0.9988574,0.0004752052,0.0001437636,0.0001299145,0.00009650495,0.0000331708,0.0001838368,0.000003314994,0.00007699925],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01923249,"threshold_uncertainty_score":0.1017124,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01702032815077397,"score_gpt":0.2991859905668676,"score_spread":0.2821656624160936,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}