{"id":"W4402665730","doi":"10.3390/toxins16090409","title":"The Role of the N-Terminal Domain of Thrombomodulin and the Potential of Recombinant Human Thrombomodulin as a Therapeutic Intervention for Shiga Toxin-Induced Hemolytic-Uremic Syndrome","year":2024,"lang":"en","type":"article","venue":"Toxins","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft; Canadian Institutes of Health Research; CanVECTOR","keywords":"Thrombomodulin; Microangiopathic hemolytic anemia; Recombinant DNA; Hemolytic anemia; Shiga toxin; Escherichia coli; Immunology; Medicine; Kidney disease; Biology; Virology; Internal medicine; Microbiology; Thrombotic thrombocytopenic purpura; Gene; Biochemistry; Thrombin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001672667,0.000154188,0.0001486839,0.00008764848,0.00005409361,0.0001447395,0.0001392871,0.0002493178,0.0003779999],"category_scores_gemma":[0.0001019637,0.00003586934,0.000108989,0.0000498621,0.0003254247,0.0001852107,0.0001053011,0.000375761,0.00006019861],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009956696,"about_ca_system_score_gemma":0.0001281435,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008215081,"about_ca_topic_score_gemma":0.0001449192,"domain_scores_codex":[0.999947,0.00002446692,0.000002952134,0.000006390617,0.000008785709,0.0000104031],"domain_scores_gemma":[0.9999548,0.00001133304,0.00001707028,0.000003724474,0.000003258305,0.000009833198],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007862423,0.0001831725,0.000543603,0.0001443867,0.00001296864,0.0001974995,0.00002341301,0.0001492485,0.9840115,0.0007393378,0.00008719071,0.01312132],"study_design_scores_gemma":[0.0003018113,0.01181737,0.01096842,0.00005625945,0.0001317808,0.00266756,0.00008754374,0.002722471,0.9595958,0.0008480597,0.01079209,0.00001082887],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9775939,0.01770445,0.003270197,0.0004591373,0.00002949456,0.00002905784,0.00003342344,0.00002307061,0.0008572068],"genre_scores_gemma":[0.9930218,0.004994932,0.001443761,0.00007147318,0.00002878459,0.00001438389,0.00004555906,0.000002840699,0.0003765686],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003779999,"threshold_uncertainty_score":0.001264572,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01174556474315928,"score_gpt":0.2758801044043746,"score_spread":0.2641345396612153,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}