{"id":"W4402665730","doi":"10.3390/toxins16090409","title":"The Role of the N-Terminal Domain of Thrombomodulin and the Potential of Recombinant Human Thrombomodulin as a Therapeutic Intervention for Shiga Toxin-Induced Hemolytic-Uremic Syndrome","year":2024,"lang":"en","type":"article","venue":"Toxins","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Bundesministerium für Bildung und Forschung; Deutsche Forschungsgemeinschaft; Canadian Institutes of Health Research; CanVECTOR","keywords":"Thrombomodulin; Microangiopathic hemolytic anemia; Recombinant DNA; Hemolytic anemia; Shiga toxin; Escherichia coli; Immunology; Medicine; Kidney disease; Biology; Virology; Internal medicine; Microbiology; Thrombotic thrombocytopenic purpura; Gene; Biochemistry; Thrombin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008972443,0.0001831482,0.0004315496,0.0000606747,0.0002690573,0.00002397974,0.0005452152,0.0001132504,0.0001571283],"category_scores_gemma":[0.0000540189,0.00009402926,0.0004200178,0.0001281949,0.0006468471,0.00005371333,0.0002118523,0.0001775564,0.000008282345],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003439886,"about_ca_system_score_gemma":0.00006699874,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002321758,"about_ca_topic_score_gemma":0.0001265175,"domain_scores_codex":[0.9982242,0.0004893921,0.0006866415,0.0002559208,0.00009448179,0.0002493753],"domain_scores_gemma":[0.9986546,0.0004186915,0.0003337148,0.0005107133,0.00006858407,0.00001368421],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004472264,0.0002814607,0.0002056423,0.0003125601,0.0007971607,0.000002764769,0.001276549,0.000002138531,0.9434038,0.04788363,0.000174573,0.005212503],"study_design_scores_gemma":[0.0109145,0.003005559,0.04149801,0.00256336,0.0015656,0.001120393,0.008663103,0.0004149076,0.6549078,0.272237,0.002588867,0.000520874],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893299,0.007667921,0.00008599443,0.0005558242,0.0008917074,0.001236119,0.00008400343,0.00002257826,0.0001260063],"genre_scores_gemma":[0.9993985,0.00003830976,0.00001157367,0.00002014127,0.00001987688,0.00008993324,0.00001964939,0.00002131537,0.0003806833],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.288496,"threshold_uncertainty_score":0.3834402,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01174556474315928,"score_gpt":0.2758801044043746,"score_spread":0.2641345396612153,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}