{"id":"W4402666045","doi":"10.1016/j.cllc.2024.09.003","title":"A Phase II Study of Neoadjuvant Opnurasib KRAS G12C Inhibitor in Patients With Surgically Resectable Non-Small Cell Lung Cancer (CCTG IND.242A): A Substudy of the IND.242 Platform Master Protocol","year":2024,"lang":"en","type":"article","venue":"Clinical Lung Cancer","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"CancerCare Manitoba; Institut universitaire de cardiologie et de pneumologie de Québec; Ottawa Hospital; Princess Margaret Cancer Centre; Kingston Health Sciences Centre; Centre Hospitalier de l’Université de Montréal; Juravinski Cancer Centre; McGill University Health Centre","funders":"Canadian Cancer Society Research Institute; Novartis Pharmaceuticals Canada; Novartis","keywords":"Medicine; Lung cancer; Master regulator; Internal medicine; Phases of clinical research; Oncology; KRAS; Cancer; Chemotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005096785,0.0004129127,0.001049302,0.0002000101,0.0001297729,0.00003727585,0.000296451,0.0002187301,0.0003729535],"category_scores_gemma":[0.00006006537,0.0002345069,0.0002497059,0.0009674041,0.0001925319,0.0001980134,0.0002374015,0.0007710889,0.000001969453],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005747322,"about_ca_system_score_gemma":0.002005924,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001808107,"about_ca_topic_score_gemma":0.003703795,"domain_scores_codex":[0.9962053,0.0001253838,0.001590587,0.000784672,0.0007795793,0.0005145141],"domain_scores_gemma":[0.9978731,0.0002853493,0.0004764544,0.0007018905,0.0004307027,0.000232453],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005641335,0.01642537,0.964915,0.001109333,0.0009877982,0.00005795564,0.004422175,0.00009977065,0.00005227071,0.000007239035,0.001842738,0.004439049],"study_design_scores_gemma":[0.1064214,0.0217629,0.8559095,0.006730549,0.002837009,0.000002284015,0.001059266,0.001287032,0.001061049,0.00001510566,0.002361026,0.0005529131],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9273911,0.0004270702,0.000008079756,0.0002113565,0.0006069579,0.07035322,0.0001856932,0.00003482397,0.0007816821],"genre_scores_gemma":[0.9481469,0.00002645385,0.00005449314,0.0001380746,0.0002279107,0.04975703,0.00002020656,0.00007525611,0.001553628],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1090055,"threshold_uncertainty_score":0.9562913,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03390580089010872,"score_gpt":0.4154961196874887,"score_spread":0.38159031879738,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}