{"id":"W4402666045","doi":"10.1016/j.cllc.2024.09.003","title":"A Phase II Study of Neoadjuvant Opnurasib KRAS G12C Inhibitor in Patients With Surgically Resectable Non-Small Cell Lung Cancer (CCTG IND.242A): A Substudy of the IND.242 Platform Master Protocol","year":2024,"lang":"en","type":"article","venue":"Clinical Lung Cancer","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"CancerCare Manitoba; Institut universitaire de cardiologie et de pneumologie de Québec; Ottawa Hospital; Princess Margaret Cancer Centre; Kingston Health Sciences Centre; Centre Hospitalier de l’Université de Montréal; Juravinski Cancer Centre; McGill University Health Centre","funders":"Canadian Cancer Society Research Institute; Novartis Pharmaceuticals Canada; Novartis","keywords":"Medicine; Lung cancer; Master regulator; Internal medicine; Phases of clinical research; Oncology; KRAS; Cancer; Chemotherapy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001965552,0.001608114,0.00205218,0.0003840945,0.0009546725,0.001242129,0.001042474,0.001372901,0.004465695],"category_scores_gemma":[0.001497027,0.0007479485,0.001864455,0.0004979842,0.0007317108,0.000605102,0.0004605137,0.003069475,0.001203633],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002596691,"about_ca_system_score_gemma":0.006544561,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01020791,"about_ca_topic_score_gemma":0.03919861,"domain_scores_codex":[0.9994442,0.000234927,0.00002363077,0.00009319841,0.000069682,0.0001344356],"domain_scores_gemma":[0.999046,0.0001032144,0.0001295629,0.00008872217,0.0001230256,0.0005093649],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.769555,0.04363935,0.01599888,0.00188239,0.002568496,0.0005084798,0.0004157768,0.00359735,0.03171121,0.0009654014,0.04797115,0.08118656],"study_design_scores_gemma":[0.7310842,0.216338,0.02713727,0.0001282439,0.001069443,0.0004229315,0.0001438638,0.00148725,0.002660397,0.0008859545,0.01856296,0.00007955953],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9064173,0.005456244,0.001300877,0.002951407,0.0007784963,0.04375952,0.0239049,0.0002679109,0.01516337],"genre_scores_gemma":[0.9106947,0.004269978,0.005384106,0.004904227,0.0006531954,0.03751167,0.02409877,0.0001295662,0.01235381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01020791,"threshold_uncertainty_score":0.02029699,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03390580089010872,"score_gpt":0.4154961196874887,"score_spread":0.38159031879738,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}