{"id":"W4402666674","doi":"10.1038/s42256-024-00887-7","title":"Zero-shot transfer of protein sequence likelihood models to thermostability prediction","year":2024,"lang":"en","type":"article","venue":"Nature Machine Intelligence","topic":"Genomics and Phylogenetic Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Waterloo","funders":"","keywords":"Thermostability; Zero (linguistics); Sequence (biology); Chemistry; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002449844,0.0001791086,0.0001508411,0.00004804449,0.00004199384,0.00001890113,0.0002486205,0.0002277093,0.00001690055],"category_scores_gemma":[0.00004183206,0.0001480874,0.0001082195,0.0001843397,0.00006814265,0.000002007399,0.00008711882,0.0002695059,0.00000497303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001773834,"about_ca_system_score_gemma":0.00007813944,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006602812,"about_ca_topic_score_gemma":0.00006375771,"domain_scores_codex":[0.998873,0.00003926061,0.0002627287,0.0004608795,0.0001603216,0.0002038082],"domain_scores_gemma":[0.9994313,0.00001634523,0.0000166929,0.0003367197,0.0001269923,0.0000720255],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007935993,0.00004104883,0.0001835595,0.00008592337,0.00006619659,0.000001841186,0.0003580808,0.001683627,0.9695583,0.002073948,0.00007057042,0.02579754],"study_design_scores_gemma":[0.00004442331,0.0004204041,0.000337427,0.00006842883,0.00002308017,0.000008815147,0.00003905469,0.003543098,0.9792711,0.01079119,0.005263242,0.0001897115],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8525927,0.01530938,0.1290222,0.000366433,0.00032765,0.0006023383,0.000413457,0.00001782419,0.001348032],"genre_scores_gemma":[0.9981303,0.0003199759,0.00110195,0.0001432033,0.000101229,0.00005113446,0.00003036539,0.00002180688,0.0001000646],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1455376,"threshold_uncertainty_score":0.603883,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02088182149323187,"score_gpt":0.2803418134828016,"score_spread":0.2594599919895697,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}