{"id":"W4402666913","doi":"10.1093/biolre/ioae135","title":"Replacing sperm with genotyped haploid androgenetic blastomeres to generate cattle with predetermined paternal genomes","year":2024,"lang":"en","type":"article","venue":"Biology of Reproduction","topic":"Reproductive Biology and Fertility","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"L'Alliance Boviteq; Université de Montréal; Cegep de Saint Hyacinthe","funders":"","keywords":"Biology; Zygote; Sperm; Embryo; Blastocyst; Genetics; Ploidy; Intracytoplasmic sperm injection; Andrology; Genomic imprinting; Blastomere; Meiosis; Parthenogenesis; Genome; Human fertilization; Embryogenesis; In vitro fertilisation; Gene; DNA methylation; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000354604,0.0002134607,0.0002170563,0.000226408,0.0001748803,0.0002827815,0.0003131907,0.0003854315,0.002959745],"category_scores_gemma":[0.0002628531,0.0001495733,0.0002167045,0.0001758809,0.000175818,0.0001514654,0.0002539658,0.0004506655,0.0007866825],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001794917,"about_ca_system_score_gemma":0.0001934097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006170803,"about_ca_topic_score_gemma":0.001207628,"domain_scores_codex":[0.9997893,0.00003927234,0.00003078579,0.00004188005,0.00007078534,0.00002804271],"domain_scores_gemma":[0.9998283,0.00005052503,0.00004963864,0.00002927982,0.0000199007,0.00002234581],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000939457,0.00001528319,0.0007997708,0.00008305866,0.00000964394,0.0001306836,0.00005346284,0.00008360128,0.9943515,0.0001953958,0.00007526996,0.004108327],"study_design_scores_gemma":[0.00004722858,0.0005921873,0.01185228,0.00003027903,0.00007181081,0.001604504,0.00009468728,0.0008520302,0.9681799,0.00009898424,0.01655845,0.00001761348],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9705959,0.002110134,0.02115307,0.0002426821,0.0001371775,0.0001607342,0.001130955,0.0002336121,0.004235696],"genre_scores_gemma":[0.9677151,0.00153137,0.01868146,0.0001408598,0.00002268459,0.00008398027,0.0020134,0.0001273704,0.00968369],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002959745,"threshold_uncertainty_score":0.009901404,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01797604536518419,"score_gpt":0.2724333270935434,"score_spread":0.2544572817283592,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}