{"id":"W4402670104","doi":"10.1200/op.24.00089","title":"Protocol-Stipulated Dose Modification to Manage Chemotherapy-Induced Peripheral Neuropathy in Children, Adolescents, and Young Adults With High-Risk Hodgkin Lymphoma","year":2024,"lang":"en","type":"article","venue":"JCO Oncology Practice","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children","funders":"National Cancer Institute; National Institutes of Health","keywords":"Medicine; Vincristine; Etoposide; Cyclophosphamide; Oncology; Internal medicine; Chemotherapy-induced peripheral neuropathy; Prednisone; Peripheral neuropathy; Chemotherapy; Vinca; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002719635,0.0002158988,0.000323942,0.0003029275,0.0002081439,0.0003146758,0.0005915533,0.0004887301,0.001524047],"category_scores_gemma":[0.004871003,0.0001540591,0.0004828465,0.0003952761,0.0002284084,0.0002994347,0.0003884353,0.0007577066,0.0001796381],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001053052,"about_ca_system_score_gemma":0.001548656,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009042899,"about_ca_topic_score_gemma":0.003167204,"domain_scores_codex":[0.998329,0.001030568,0.000226856,0.0001090647,0.0001985734,0.0001059627],"domain_scores_gemma":[0.9980168,0.0005607594,0.0008765585,0.0001584109,0.0001268721,0.0002605937],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.07829941,0.01126345,0.1877381,0.002278032,0.00120247,0.0002673914,0.000616261,0.007942941,0.01056356,0.0009966262,0.009072728,0.6897589],"study_design_scores_gemma":[0.07525413,0.2212785,0.6180255,0.001957079,0.001148855,0.001777582,0.0004327578,0.005050502,0.01347075,0.001244953,0.06028928,0.0000700545],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9752661,0.008306121,0.001661662,0.0006174719,0.0001149517,0.006170549,0.0009027351,0.00008797535,0.00687239],"genre_scores_gemma":[0.9879288,0.001490305,0.003971112,0.0007326648,0.00005453737,0.0042728,0.0008653996,0.00001058246,0.0006738771],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002719635,"threshold_uncertainty_score":0.01438302,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01621319297402094,"score_gpt":0.3474002585708698,"score_spread":0.3311870655968489,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}