{"id":"W4402674819","doi":"10.1007/s40256-024-00682-0","title":"Efficacy of Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors in Patients with Heterozygous Familial Hypercholesterolemia: A Meta-analysis","year":2024,"lang":"en","type":"review","venue":"American Journal of Cardiovascular Drugs","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Surrey Place Centre; University of British Columbia; University of British Columbia Hospital; St. Paul's Hospital","funders":"","keywords":"Kexin; Proprotein convertase; Medicine; Subtilisin; Familial hypercholesterolemia; Meta-analysis; PCSK9; Pharmacotherapy; Pharmacology; Internal medicine; Oncology; Cholesterol; LDL receptor; Lipoprotein; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","metaepi_broad"],"consensus_categories":["metaepi_broad"],"category_scores_codex":[0.003306909,0.001007277,0.01715375,0.002112132,0.00004214886,0.00005303288,0.0004774683,0.0003246855,0.00002110508],"category_scores_gemma":[0.000208484,0.0005935954,0.02715601,0.003923651,0.0004624827,0.0001491639,0.0001324081,0.00188196,0.00001677085],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004844356,"about_ca_system_score_gemma":0.001642591,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007661676,"about_ca_topic_score_gemma":0.00001095238,"domain_scores_codex":[0.9909145,0.001560132,0.00269762,0.0008809994,0.003330647,0.0006161066],"domain_scores_gemma":[0.9946932,0.0001376174,0.001620902,0.002058025,0.0009993744,0.0004909049],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.0004597781,0.0002895119,0.0001071563,0.005424594,0.467213,0.0004956893,0.0002105031,0.0001132675,1.041529e-7,6.248683e-7,0.00002344756,0.5256624],"study_design_scores_gemma":[0.003193262,0.002230962,0.0003812295,0.003569138,0.8044482,0.0003652803,0.0001231583,0.000001738578,0.000006864539,0.000001009739,0.1851612,0.0005179911],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0339211,0.9631618,0.00006699328,0.00002669871,0.0002196001,0.002472132,0.00007230785,0.00002185623,0.00003748936],"genre_scores_gemma":[0.07325625,0.9251814,0.0005700871,0.00006303052,0.0004684424,0.00008600114,0.0001094721,0.0002308688,0.00003441264],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.5251443,"threshold_uncertainty_score":0.9996516,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02671973774396498,"score_gpt":0.2941128083359507,"score_spread":0.2673930705919857,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}