{"id":"W4402675350","doi":"10.2337/dc24-1375","title":"A Glycemic Threshold Above Which the Improvement of β-Cell Function and Glycemia in Response to Insulin Therapy Is Amplified in Early Type 2 Diabetes: The Reversal of Glucotoxicity","year":2024,"lang":"en","type":"article","venue":"Diabetes Care","topic":"Diabetes Management and Research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; McMaster University; University of Toronto; Western University; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research","keywords":"Medicine; Internal medicine; Type 2 diabetes; Endocrinology; Glycemic; Insulin resistance; Diabetes mellitus; Insulin; Insulin glargine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008010513,0.0001903549,0.0003424092,0.0003562268,0.00003872013,0.00005230229,0.0002293423,0.0001157388,0.00003688402],"category_scores_gemma":[0.0001301361,0.000113361,0.00007756619,0.001471051,0.0001188916,0.00008930158,0.0001718728,0.0004085267,0.00001896271],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001001686,"about_ca_system_score_gemma":0.0001252505,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005761721,"about_ca_topic_score_gemma":0.00005094916,"domain_scores_codex":[0.9983188,0.0001030156,0.0003801027,0.0003617945,0.0004381784,0.0003981254],"domain_scores_gemma":[0.9988021,0.0003760679,0.00006364711,0.0004873963,0.0002023664,0.00006847473],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.008862076,0.0001941356,0.4870477,0.00122287,0.0001719829,0.000004663357,0.009286876,0.00002422121,0.469278,0.00006751181,0.0007679492,0.02307194],"study_design_scores_gemma":[0.00718538,0.009043909,0.7981009,0.001554785,0.0001362713,8.699686e-8,0.00410223,0.001740839,0.1736814,0.0005927607,0.003501065,0.0003603623],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920601,0.00427827,0.000001146887,0.001629104,0.0001719811,0.001452976,0.00003950363,0.00002168712,0.0003452415],"genre_scores_gemma":[0.9986486,0.0002416979,0.0000131217,0.0007085354,0.00004628257,0.0001000014,0.00001650705,0.00002981973,0.0001954516],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3110532,"threshold_uncertainty_score":0.4622729,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01317324932649865,"score_gpt":0.2634227918401766,"score_spread":0.250249542513678,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}