{"id":"W4402676903","doi":"10.1101/2024.09.16.613264","title":"A PROXIMITY LIGATION SCREEN IDENTIFIES SNAT2 AS A NOVEL TARGET OF THE MARCH1 E3 UBIQUITIN LIGASE","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute; Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Diabète Québec","keywords":"Ubiquitin ligase; Ubiquitin; Ligation; DNA ligase; Cell biology; Chemistry; Biology; Molecular biology; DNA; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001311661,0.0004192387,0.0003661418,0.0004241341,0.0002788872,0.0003288362,0.0003474677,0.0004500798,0.001716924],"category_scores_gemma":[0.0001391939,0.0001519987,0.0003692603,0.0003155885,0.0001529609,0.0001244299,0.0003495479,0.0003256382,0.0009991965],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004228814,"about_ca_system_score_gemma":0.0001259382,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006567937,"about_ca_topic_score_gemma":0.001180983,"domain_scores_codex":[0.9997568,0.00003174408,0.0000185549,0.0000617843,0.0000902614,0.00004096108],"domain_scores_gemma":[0.9998893,0.00002633557,0.00002671643,0.0000097722,0.00001608421,0.00003187577],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005519886,0.00001585476,0.0002344635,0.00001148097,0.000004430426,0.0001001815,0.000005753411,0.00002535696,0.9991146,0.00001675299,0.00002722213,0.0003888749],"study_design_scores_gemma":[0.000006988721,0.00013966,0.005734672,0.000001919354,0.00001685761,0.0007807994,0.00002659688,0.001022314,0.9905267,0.00001418212,0.001725147,0.000004195527],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923486,0.0006642232,0.004508902,0.0001166823,0.00002018872,0.00004327566,0.0009815218,0.0001667923,0.001149905],"genre_scores_gemma":[0.9864752,0.0003227892,0.005951399,0.00007607738,0.000005440224,0.00003549664,0.003279265,0.00004119179,0.003813179],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001716924,"threshold_uncertainty_score":0.005743623,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0131778923287782,"score_gpt":0.2295867869977834,"score_spread":0.2164088946690052,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}