{"id":"W4402684921","doi":"10.14740/jmc4287","title":"Combination Therapy With Asciminib and Ponatinib as a Bridge to Brexucabtagene Autoleucel and Maintenance in a Patient With Relapsed Refractory Philadelphia Positive B-Cell Acute Lymphoblastic Leukemia","year":2024,"lang":"en","type":"article","venue":"Journal of Medical Cases","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Medicine; Ponatinib; Lymphoblastic Leukemia; Refractory (planetary science); Maintenance therapy; Bridge (graph theory); Internal medicine; Oncology; Leukemia; Surgery; Myeloid leukemia; Chemotherapy; Dasatinib","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007286374,0.0002070132,0.0004508573,0.0004219121,0.00004597687,0.00006954512,0.0001006497,0.0001317055,0.0002387901],"category_scores_gemma":[0.000336538,0.0001261517,0.00004726446,0.0004432102,0.0002260075,0.0001515404,0.00004732913,0.0006974765,0.000003072142],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004627454,"about_ca_system_score_gemma":0.001523108,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000163774,"about_ca_topic_score_gemma":0.00004873611,"domain_scores_codex":[0.9972309,0.0001295393,0.000441428,0.0002892956,0.001614695,0.0002941213],"domain_scores_gemma":[0.9981422,0.0007531951,0.0001360725,0.000131641,0.0002449252,0.0005919562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"case_report","study_design_scores_codex":[0.08377293,0.003266624,0.00421654,0.0008705071,0.001533494,0.3465888,0.01693389,0.00003391367,0.07160376,0.0004187475,0.01127576,0.4594851],"study_design_scores_gemma":[0.10182,0.1712624,0.2183704,0.02581951,0.0009098685,0.4087954,0.004577835,0.007274961,0.02588162,0.0003253253,0.03346373,0.001498914],"study_design_candidate":"case_report","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986347,0.002528159,0.0001420255,0.01011108,0.00009051755,0.0004414429,0.00001286325,0.00001666095,0.0003102672],"genre_scores_gemma":[0.9953659,0.002273581,0.0002303159,0.001572976,0.000111556,0.00001500651,0.000006441919,0.00004001949,0.0003842163],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4579861,"threshold_uncertainty_score":0.5144315,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01890413733043029,"score_gpt":0.30797661611468,"score_spread":0.2890724787842497,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}