{"id":"W4402690505","doi":"10.1080/10985549.2024.2401465","title":"A Genome Wide CRISPR Screen Reveals That HOXA9 Promotes Enzalutamide Resistance in Prostate Cancer","year":2024,"lang":"en","type":"article","venue":"Molecular and Cellular Biology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Western University","funders":"Canadian Institutes of Health Research; Cancer Research Society","keywords":"Biology; Enzalutamide; CRISPR; Prostate cancer; Genetics; Genome editing; Genome; Computational biology; Cancer research; Cancer; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001048658,0.0002815285,0.0003093008,0.0002397584,0.0001647219,0.0002882641,0.0002037669,0.0002680915,0.002221302],"category_scores_gemma":[0.00008548293,0.0001472091,0.0002632333,0.0001695405,0.000178654,0.0000599681,0.0001989646,0.0004880019,0.0003707181],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002566663,"about_ca_system_score_gemma":0.000268772,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001891088,"about_ca_topic_score_gemma":0.004455707,"domain_scores_codex":[0.9998683,0.00001288788,0.00001092289,0.00003333843,0.00004598022,0.00002852484],"domain_scores_gemma":[0.9999366,0.00001683341,0.00001358934,0.000007238425,0.00000589848,0.00001993821],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007548075,0.00002917754,0.000450009,0.0000280645,0.00001321645,0.0001054003,0.000008536224,0.0002653236,0.9969307,0.00008177815,0.00014122,0.001871207],"study_design_scores_gemma":[0.00002891291,0.000418931,0.01481157,0.000008391051,0.00006597536,0.0006762687,0.00004831024,0.003647314,0.9746289,0.00007648358,0.005575619,0.00001323898],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9835436,0.0008816507,0.007512359,0.0002407271,0.00005188251,0.00006966988,0.00322944,0.0007703318,0.003700293],"genre_scores_gemma":[0.9903023,0.0005195253,0.003332386,0.0001101597,0.000003828395,0.00003170337,0.001372165,0.00004980017,0.004278213],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002221302,"threshold_uncertainty_score":0.00743103,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01818317752483063,"score_gpt":0.3041824384706338,"score_spread":0.2859992609458031,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}