{"id":"W4402693981","doi":"10.1101/2024.09.16.613289","title":"Proof of concept study deploying CRISPR inhibition and activation opens new avenues for systematic biological exploration in zebrafish","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research","keywords":"Zebrafish; CRISPR; Key (lock); Computational biology; Biology; Computer science; Nanotechnology; Genetics; Ecology; Materials science; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001311884,0.000913314,0.000601244,0.0004653015,0.0004187803,0.0007694575,0.0009141614,0.001042324,0.008533512],"category_scores_gemma":[0.0005639588,0.0004140086,0.0006105487,0.000206993,0.0005152188,0.0005414963,0.0006221235,0.001310752,0.002713936],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007965891,"about_ca_system_score_gemma":0.001288769,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001436145,"about_ca_topic_score_gemma":0.001752155,"domain_scores_codex":[0.9993564,0.00005205137,0.00004907072,0.0001280927,0.0003257532,0.00008866227],"domain_scores_gemma":[0.9996411,0.00004202779,0.00008412218,0.00005435046,0.00009772583,0.00008071595],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006674391,0.00006281981,0.0001477575,0.0002161113,0.00001579598,0.0002450909,0.00003140216,0.0003508057,0.9886509,0.002849832,0.001161659,0.006201143],"study_design_scores_gemma":[0.0001325369,0.0010996,0.001002727,0.00006269322,0.00005146078,0.0009185585,0.00004186374,0.002738334,0.9337827,0.0006960375,0.05942626,0.00004726505],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.3057635,0.006285878,0.6187623,0.002632075,0.001936021,0.004873656,0.0114573,0.007128779,0.04116064],"genre_scores_gemma":[0.6060361,0.004676015,0.3437763,0.0007254432,0.0001039515,0.00366429,0.0064576,0.0008538351,0.03370639],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.008533512,"threshold_uncertainty_score":0.02854741,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02500979893719426,"score_gpt":0.2839450075390673,"score_spread":0.2589352086018731,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}