{"id":"W4402704697","doi":"10.3390/ph17091212","title":"Pharmacological Inhibition of Endogenous Hydrogen Sulfide Production Slows Bladder Cancer Progression in an Intravesical Murine Model","year":2024,"lang":"en","type":"article","venue":"Pharmaceuticals","topic":"Sulfur Compounds in Biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lawson Health Research Institute; London Health Sciences Centre; Western University","funders":"Schulich School of Medicine and Dentistry; Schulich School of Medicine and Dentistry, Western University; Canadian Urological Association Scholarship Fund; Canadian Urological Association","keywords":"Gemcitabine; Bladder cancer; In vivo; Apoptosis; Medicine; Cancer research; Viability assay; Angiogenesis; Neovascularization; Cancer cell; Cancer; Pharmacology; Pathology; Chemistry; Internal medicine; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002561432,0.0005196386,0.0004164465,0.0003712576,0.0001521479,0.0002849118,0.0003711957,0.0004205359,0.001007108],"category_scores_gemma":[0.0001077653,0.0002377196,0.0003949721,0.0001861455,0.0003429623,0.0003260333,0.0001632941,0.001109895,0.0001662048],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004204253,"about_ca_system_score_gemma":0.000474228,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001153256,"about_ca_topic_score_gemma":0.002301786,"domain_scores_codex":[0.9998245,0.00003367728,0.00001780393,0.00003457271,0.00003965123,0.00004984855],"domain_scores_gemma":[0.9998491,0.00001682649,0.00005618859,0.00001943087,0.00001312031,0.00004536819],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007329757,0.0002896253,0.0001837766,0.00006733622,0.0000127366,0.00003852791,0.00002153529,0.0001713666,0.9963862,0.00007467256,0.0000863528,0.001934914],"study_design_scores_gemma":[0.00006011934,0.003514873,0.001432632,0.000007993316,0.00003143437,0.00009754378,0.00002503837,0.001325079,0.9923347,0.00003000178,0.001135391,0.000005189023],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950042,0.001454577,0.002118751,0.0002044094,0.00006702117,0.00004755805,0.0002874772,0.0001398086,0.000676197],"genre_scores_gemma":[0.9929845,0.001632123,0.002427203,0.00007570338,0.00002353153,0.00007391234,0.000314655,0.00002058965,0.002447707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001153256,"threshold_uncertainty_score":0.003369093,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08212493639097355,"score_gpt":0.4004415798162466,"score_spread":0.318316643425273,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}