{"id":"W4402704931","doi":"10.1016/j.annonc.2024.08.1697","title":"1616P Circulating tumour DNA (ctDNA) measurements and PET-imaging to evaluate response in a phase Ib trial of metastatic castration-resistant prostate cancer (mCRPC) treated with Lutetium-177-PSMA-617 (LuPSMA) plus pembrolizumab (PRINCE)","year":2024,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Medical Research Council; U.S. Army; EMD Serono; Genentech; National Institutes of Health; Australian and New Zealand Urogenital and Prostate Cancer Trials Group; Cilag; Astellas Pharma; Eisai; Prostate Cancer Foundation; Bristol-Myers Squibb; Eli Lilly and Company; UK Research and Innovation; AstraZeneca; American Society of Clinical Oncology; Ipsen; Peter MacCallum Cancer Centre; University of New South Wales; BeiGene; Sanofi; Amgen; Pfizer; Prostate Cancer UK","keywords":"Medicine; Prostate cancer; Lutetium; Oncology; Cancer; Nuclear medicine; Prostate; Cancer research; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0015704,0.001002667,0.00147404,0.0003945587,0.0003218886,0.0008273267,0.0006306298,0.001337241,0.002340053],"category_scores_gemma":[0.0009713849,0.0005444086,0.0007241385,0.0004006934,0.0006699938,0.0006975665,0.0002494976,0.002462747,0.0006815458],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008389369,"about_ca_system_score_gemma":0.000854782,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008023779,"about_ca_topic_score_gemma":0.001728943,"domain_scores_codex":[0.9995967,0.0001790405,0.00002305534,0.00007667037,0.00004130625,0.00008325396],"domain_scores_gemma":[0.999464,0.0001205186,0.00008033231,0.00004218288,0.00003143219,0.0002615566],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7363622,0.03660417,0.02256973,0.0004503636,0.001760132,0.0003605158,0.0004298983,0.004901411,0.06436447,0.0003226545,0.002469766,0.1294048],"study_design_scores_gemma":[0.2749884,0.6279724,0.06777046,0.00005096063,0.001160655,0.0008146838,0.0001624683,0.006354462,0.01603074,0.0004219206,0.004196167,0.00007655607],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996645,0.001076584,0.000194636,0.0002822285,0.00006106299,0.0003926937,0.0003029268,0.00004363779,0.001001195],"genre_scores_gemma":[0.9961874,0.0004457411,0.0007191274,0.0003074436,0.00004841453,0.0004653184,0.0006736222,0.00001466327,0.001138283],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002340053,"threshold_uncertainty_score":0.008305192,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1693996611291912,"score_gpt":0.4659190459110379,"score_spread":0.2965193847818467,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}