{"id":"W4402713089","doi":"10.1101/2024.09.12.612675","title":"A Comprehensive Proteogenomic and Spatial Analysis of Innate and Acquired Resistance of Metastatic Melanoma to Immune Checkpoint Blockade Therapies","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire de Sherbrooke; Université de Sherbrooke","funders":"","keywords":"Blockade; Metastatic melanoma; Immune checkpoint; Innate immune system; Melanoma; Medicine; Cancer research; Immune system; Immunology; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001029851,0.0001396546,0.000171974,0.0006609528,0.000141338,0.0001801547,0.00007114447,0.0001129422,0.0004688261],"category_scores_gemma":[0.0001168701,0.00007531131,0.0001883616,0.0003703843,0.00008773528,0.00009782887,0.0001473318,0.000133839,0.000114003],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001063259,"about_ca_system_score_gemma":0.0001578024,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006512416,"about_ca_topic_score_gemma":0.001419575,"domain_scores_codex":[0.9999354,0.000007085522,0.000004103066,0.00001676451,0.0000240125,0.00001273808],"domain_scores_gemma":[0.9999465,0.000006414659,0.0000162366,0.000006497098,0.00001377494,0.00001054264],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001594481,0.00002538527,0.01567508,0.00004133243,0.00002875782,0.00007671108,0.00003315642,0.0003691752,0.9766576,0.0000555596,0.0001141993,0.006763535],"study_design_scores_gemma":[0.0000128272,0.0004086681,0.7280606,0.00001580022,0.0001343442,0.001286515,0.0002635197,0.0112135,0.2548852,0.0003038154,0.003395273,0.00002002493],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995756,0.0005400436,0.00195758,0.0000354217,0.000003678993,0.00001735878,0.00127493,0.00003757525,0.0003773702],"genre_scores_gemma":[0.9938611,0.0004064765,0.003042293,0.00003496551,0.000006610877,0.00003150714,0.001864829,0.0000101483,0.000742009],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006609528,"threshold_uncertainty_score":0.001568377,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0157264205779999,"score_gpt":0.2464826271153223,"score_spread":0.2307562065373224,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}