{"id":"W4402717585","doi":"10.1016/j.jaci.2026.04.032","title":"BCR ligation selectively inhibits IgE class switch recombination","year":2024,"lang":"en","type":"preprint","venue":"Journal of Allergy and Clinical Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; University of California, San Francisco; National Institutes of Health; Pew Charitable Trusts","keywords":"breakpoint cluster region; Ligation; Immunoglobulin class switching; Recombination; Immunoglobulin E; Class (philosophy); Chemistry; Biology; Genetics; Molecular biology; Computer science; Antibody; B cell; Receptor; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002343567,0.0002680082,0.0002844263,0.0002429517,0.0001569229,0.0003727174,0.0002883042,0.0004050134,0.005474465],"category_scores_gemma":[0.0003189888,0.0002427558,0.0001976411,0.0001470391,0.0002143534,0.0001517308,0.00030793,0.000636976,0.00105344],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002169503,"about_ca_system_score_gemma":0.0002061275,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004315173,"about_ca_topic_score_gemma":0.0004862568,"domain_scores_codex":[0.9996254,0.00007312954,0.00001603018,0.00004075473,0.00006416836,0.0001804952],"domain_scores_gemma":[0.9998046,0.0001030456,0.0000205423,0.00003040351,0.000009089767,0.00003239927],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004882843,0.00007443441,0.00008138909,0.00003157958,0.000007946904,0.00006834747,0.000008182785,0.0001104994,0.9965804,0.0003266149,0.0002478321,0.001974512],"study_design_scores_gemma":[0.00007596365,0.000246056,0.001065714,0.000003519706,0.00001681611,0.0002272942,0.0000066122,0.0005669769,0.9953983,0.00008931017,0.002299566,0.000003818521],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9839962,0.001305094,0.002111573,0.0002511011,0.0001152955,0.00003487795,0.0003505785,0.0003026643,0.01153263],"genre_scores_gemma":[0.9952381,0.000395643,0.0005345351,0.00006148264,0.00003828584,0.00001503206,0.000272258,0.00004004676,0.003404624],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005474465,"threshold_uncertainty_score":0.01831394,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02392896381309909,"score_gpt":0.2968096040779493,"score_spread":0.2728806402648501,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}