{"id":"W4402722290","doi":"10.1101/2024.09.20.614127","title":"Functional characterization of N-acetyltransferase 10 (NAT10) in Leishmania mexicana","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Chemical Reactions and Isotopes","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cegep de Saint Hyacinthe","funders":"National Institutes of Health; National Institute of Allergy and Infectious Diseases; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Leishmania mexicana; Acetyltransferase; Leishmania; Cell biology; Characterization (materials science); Biology; Chemistry; Biochemistry; Computer science; Nanotechnology; Materials science; Acetylation; Parasite hosting; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001217758,0.0003021231,0.0001264565,0.0002302207,0.0001313993,0.0002013527,0.0002224808,0.0002300391,0.00083407],"category_scores_gemma":[0.0001245929,0.0001324607,0.0002347264,0.0001704814,0.0001631934,0.0001084034,0.0001543573,0.0002663458,0.0004688351],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002885811,"about_ca_system_score_gemma":0.0001458813,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001554929,"about_ca_topic_score_gemma":0.001696366,"domain_scores_codex":[0.999935,0.00001155891,0.000007495078,0.00001692654,0.00001678944,0.00001222132],"domain_scores_gemma":[0.9998889,0.00001779494,0.00003292274,0.00001877342,0.00001769861,0.00002400156],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003924469,0.000009948309,0.0002131066,0.00002002569,0.000002019004,0.00002094532,0.000007249119,0.00001833295,0.9992912,0.00002659689,0.000009950548,0.0003415019],"study_design_scores_gemma":[0.00002000705,0.0002898009,0.02049674,0.000008691874,0.00002810742,0.0005110377,0.00007035884,0.0009508685,0.9697547,0.00005558061,0.007806894,0.00000720957],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935917,0.0008144167,0.002621204,0.0001019675,0.00001404629,0.00002735213,0.001892657,0.00004520528,0.0008914178],"genre_scores_gemma":[0.9845423,0.0005063421,0.004143533,0.00005768592,0.000009206407,0.00003909737,0.006587374,0.00004166889,0.004072897],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001554929,"threshold_uncertainty_score":0.003091693,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04844373083931779,"score_gpt":0.3164433820080829,"score_spread":0.2679996511687651,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}