{"id":"W4402722290","doi":"10.1101/2024.09.20.614127","title":"Functional characterization of N-acetyltransferase 10 (NAT10) in Leishmania mexicana","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Chemical Reactions and Isotopes","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Cegep de Saint Hyacinthe","funders":"National Institutes of Health; National Institute of Allergy and Infectious Diseases; Conselho Nacional de Desenvolvimento Científico e Tecnológico; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Leishmania mexicana; Acetyltransferase; Leishmania; Cell biology; Characterization (materials science); Biology; Chemistry; Biochemistry; Computer science; Nanotechnology; Materials science; Acetylation; Parasite hosting; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0006027759,0.0004453079,0.0005672859,0.0003862403,0.00008020859,0.00005285566,0.0003109953,0.001061876,0.002131927],"category_scores_gemma":[0.0001202025,0.0004826277,0.0002022097,0.0005874023,0.0001812487,0.0001021569,0.0002812725,0.002157825,0.0002161556],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002787596,"about_ca_system_score_gemma":0.0005719237,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006666881,"about_ca_topic_score_gemma":0.000006948009,"domain_scores_codex":[0.9976473,0.0001719506,0.0007206915,0.0007489094,0.0002781055,0.0004329758],"domain_scores_gemma":[0.9986336,0.0001294273,0.000218421,0.0004628408,0.0003178882,0.0002378706],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001667403,0.0003641358,0.0021776,0.0005694691,0.0002062728,0.00004195506,0.00001253407,0.00006841565,0.9943615,0.001315772,0.0006988126,0.00001679148],"study_design_scores_gemma":[0.0007012412,0.00004525531,0.03692845,0.0002596527,0.0002313484,4.196687e-8,0.000002130807,0.0009486266,0.9142216,0.0000151618,0.04613028,0.0005162382],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945879,0.0005968148,0.0001530341,0.0005668607,0.002352886,0.0005645161,0.0008687714,0.0001949467,0.0001142479],"genre_scores_gemma":[0.9980206,0.000654775,0.0001268464,0.0002756994,0.0005204829,0.0002244486,0.000006780143,0.00008567086,0.00008470462],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08013994,"threshold_uncertainty_score":0.9997625,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04844373083931779,"score_gpt":0.3164433820080829,"score_spread":0.2679996511687651,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}