{"id":"W4402729372","doi":"10.17952/37eps.2024.p1084","title":"Synthesis of Aza-Amanitins to Enhance Cytotoxicity for Targeted Cancer Therapeutics","year":2024,"lang":"en","type":"article","venue":"","topic":"Pharmacological Effects of Natural Compounds","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Cytotoxicity; Cancer; Cancer research; Computer science; Chemistry; Medicine; Internal medicine; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0007541106,0.0002999246,0.0004346215,0.0001730961,0.0001585669,0.00003301555,0.0004776727,0.0003521891,0.002556113],"category_scores_gemma":[0.0002169387,0.0002355888,0.0002450202,0.0004870642,0.000154905,0.000131831,0.0001155791,0.0006531843,0.0001133303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001533445,"about_ca_system_score_gemma":0.0001252686,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002481587,"about_ca_topic_score_gemma":0.00004225565,"domain_scores_codex":[0.9980515,0.0002928207,0.0004219541,0.0004812132,0.0001891472,0.0005633917],"domain_scores_gemma":[0.9954118,0.003905672,0.00007758956,0.0001695824,0.0001956456,0.0002396869],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006550897,0.0002246688,0.0001063955,0.0003102962,0.0005590574,0.00001414565,0.0001410341,0.0003577669,0.9206163,0.00186725,0.01980983,0.05533818],"study_design_scores_gemma":[0.0002174164,0.0002639875,0.0002981412,0.00004565025,0.0003178834,0.000002960737,0.00002155272,0.007622448,0.850271,0.000604779,0.140061,0.0002731791],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9740708,0.004056262,0.002458558,0.007759673,0.002790605,0.001995752,0.0007094908,0.0005590222,0.005599857],"genre_scores_gemma":[0.9869202,0.000305516,0.001201339,0.008847526,0.0003890262,0.0007717414,0.000008658603,0.00004012066,0.001515825],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1202512,"threshold_uncertainty_score":0.9983557,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1220092836468747,"score_gpt":0.4948781236564426,"score_spread":0.3728688400095679,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}