{"id":"W4402732173","doi":"10.1002/alz.14239","title":"Self‐ and study partner–reported cognitive decline in older adults without dementia: The role of α‐synuclein and amyloid biomarkers in the Alzheimer's Disease Neuroimaging Initiative","year":2024,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; Servier; Eisai; Northern California Institute for Research and Education; Biogen; BioClinica; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Disease Neuroimaging Initiative; Novartis Pharmaceuticals Corporation; Pfizer; Bristol-Myers Squibb; Eli Lilly and Company; National Institute on Aging; Alzheimer's Association; University of Southern California; H. Lundbeck A/S; U.S. Department of Veterans Affairs","keywords":"Dementia; Cognitive decline; Neuroimaging; Disease; Amyloid (mycology); Cognition; Medicine; Gerontology; Psychology; Alzheimer's disease; Psychiatry; Neuroscience; Internal medicine; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00233165,0.0003701461,0.0005906662,0.001240879,0.0004365617,0.001254037,0.0004785871,0.0006490206,0.001087029],"category_scores_gemma":[0.006285981,0.0001995122,0.0005144106,0.001485251,0.0002739483,0.000726982,0.0008597993,0.0005948693,0.0002705387],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001994011,"about_ca_system_score_gemma":0.0002172318,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002929075,"about_ca_topic_score_gemma":0.005418858,"domain_scores_codex":[0.9990678,0.0003124256,0.000168665,0.0001800285,0.0002050969,0.00006603987],"domain_scores_gemma":[0.9952595,0.0006258071,0.002717294,0.0002007961,0.0005463855,0.0006502389],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.00007942238,0.00003021093,0.9979982,0.00002433863,0.00006965687,0.00003934626,0.00007736084,0.00001088351,0.00002686236,0.000005723633,0.00007169469,0.001566319],"study_design_scores_gemma":[0.000004176107,0.00007143918,0.9993138,0.00002382943,0.00004326032,0.0001563849,0.0001578896,0.00007181043,0.00002180701,0.00002165006,0.0001104651,0.000003554797],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947054,0.003213737,0.00007726106,0.000165818,0.00002580767,0.00001793587,0.0007186817,0.000005085108,0.001070294],"genre_scores_gemma":[0.9986219,0.0005498496,0.00008916289,0.00006367974,0.00003391239,0.0000135582,0.0004670104,0.000001455711,0.0001594035],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002929075,"threshold_uncertainty_score":0.01233107,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0238359664731678,"score_gpt":0.3245016702534629,"score_spread":0.3006657037802951,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}