{"id":"W4402732746","doi":"10.1001/jamaneurol.2024.3162","title":"Four-Repeat Tau Seeding in the Skin of Patients With Progressive Supranuclear Palsy","year":2024,"lang":"en","type":"article","venue":"JAMA Neurology","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto; University Health Network","funders":"","keywords":"Progressive supranuclear palsy; Medicine; Tau pathology; Pathology; Disease; Alzheimer's disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002174988,0.0001937118,0.0001871808,0.0008767833,0.0004857979,0.0004185057,0.0001357652,0.000368151,0.001460328],"category_scores_gemma":[0.001171244,0.0001103973,0.0001916909,0.0004118943,0.0003374395,0.0003440357,0.0002510573,0.0002875161,0.0001990318],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003169034,"about_ca_system_score_gemma":0.0002505599,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002062752,"about_ca_topic_score_gemma":0.002865053,"domain_scores_codex":[0.9998221,0.00004542909,0.00001749388,0.00003366811,0.0000342667,0.00004702133],"domain_scores_gemma":[0.9995489,0.0001694939,0.0001440089,0.00001726145,0.00005454093,0.00006569093],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007338212,0.00008865712,0.8631695,0.0001367646,0.00007832878,0.08774336,0.001495856,0.0003229465,0.01266649,0.0002486621,0.0006438552,0.03267179],"study_design_scores_gemma":[0.00002831199,0.0006774903,0.8049008,0.0001064522,0.0001144888,0.1844523,0.0029566,0.000523186,0.004050716,0.0004851886,0.001680205,0.00002426695],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994392,0.001334599,0.0001664664,0.0001644244,0.00001574216,0.000009058613,0.00004005647,0.00001212827,0.003865567],"genre_scores_gemma":[0.9988667,0.0006074749,0.0001120358,0.00007895808,0.00002055583,0.00000272452,0.00002061081,0.000002830425,0.0002881866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002062752,"threshold_uncertainty_score":0.004885256,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01174871228256097,"score_gpt":0.2468333393458243,"score_spread":0.2350846270632634,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}